ArticleCellular immunology2010
Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation.
Article in Cellular immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Vaccine responses in ageing and chronic viral infection.Oxford open immunology · 2021Review
- Activation of IL-10+ B cells: A novel immunomodulatory mechanism for therapeutic bacterial suspensions.SAGE open medicine · 2020Article
- Lipoxin BJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment.Journal of neuroinflammation · 2017Article
- Lipoxin A₄ modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism.European journal of immunology · 2014Article
- Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies.The Journal of clinical investigation · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Worldwide the elderly population is increasing. The elderly show deficiencies in immune function. B lymphocytes are essential elements of the immune system responsible for antibody production. This laboratory previously showed that activated human B cells isolated from young adults express cyclooxygenase-2 (Cox-2) and that Cox-2 is essential for optimal antibody responses. Recent data suggests that Cox-2 expression decreases with age in mouse bone tissue. There is no information regarding Cox-2 expression in B cells from older human subjects. We investigated the expression and activity of Cox-2 in naïve and memory B cells from older people. We show that B cells from older subjects show similar Cox-2 protein expression and activity, antibody production and proliferation compared to younger people. However, we found that activated memory B cells from older people produce higher levels of IL-6 and IL-10 compared to young adults. Therefore, the dysregulated cytokine production could contribute to immune senescence in the elderly.
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