ArticleNeuroscience2010
Synaptic changes underlying the strengthening of GABA/glycinergic connections in the developing lateral superior olive.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- GABA corelease guides the functional maturation of glycinergic synapses in an auditory sound localization circuit.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Developmental auditory deprivation in one ear impairs brainstem binaural processing and reduces spatial hearing acuity.PLoS biology · 2025Article
- Structural and Functional Development of Inhibitory Connections from the Medial Nucleus of the Trapezoid Body to the Superior Paraolivary Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The CleLife · 2022Article
- Long-term potentiation of glycinergic synapses by semi-natural stimulation patterns during tonotopic map refinement.Scientific reports · 2020Article
- Synaptic Inhibition of Medial Olivocochlear Efferent Neurons by Neurons of the Medial Nucleus of the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- GABA is a modulator, rather than a classical transmitter, in the medial nucleus of the trapezoid body-lateral superior olive sound localization circuit.The Journal of physiology · 2019Article
- Does acute heat stress differentially-modulate expression of ionotropic neurotransmitter receptors in the RVLM of young and aged F344 rats?Neuroscience letters · 2018Article
- Specific synaptic input strengths determine the computational properties of excitation-inhibition integration in a sound localization circuit.The Journal of physiology · 2018Article
- Ultrastructural basis of strong unitary inhibition in a binaural neuron.The Journal of physiology · 2018Article
- Article
- Neurotransmitters and Receptors Changes in Medial Nucleus of the Trapezoid Body (MNTB) of Early-Developmental Rats with Single-Side Deafness.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Acoustic trauma slows AMPA receptor-mediated EPSCs in the auditory brainstem, reducing GluA4 subunit expression as a mechanism to rescue binaural function.The Journal of physiology · 2016Article
- Hyperpolarization-independent maturation and refinement of GABA/glycinergic connections in the auditory brain stem.Journal of neurophysiology · 2016Article
- Excitation by Axon Terminal GABA Spillover in a Sound Localization Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.Genetics · 2015Article
- Noradrenergic refinement of glutamatergic neuronal circuits in the lateral superior olivary nucleus before hearing onset.Journal of neurophysiology · 2015Article
- Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin.Journal of neurophysiology · 2014Article
- Dynamic fidelity control to the central auditory system: synergistic glycine/GABAergic inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Before hearing onset, the topographic organization of the auditory GABA/glycinergic pathway from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO) is refined by synaptic silencing and strengthening. The synaptic mechanisms underlying the developmental strengthening of maintained MNTB-LSO connections are unknown. Here we address this question using whole-cell recordings from LSO neurons in slices prepared from prehearing mice. Minimal and maximal stimulation techniques demonstrated that during the first two postnatal weeks, individual LSO neurons lose about 55% of their initial presynaptic MNTB partners while maintained single-fiber connections become about 14-fold stronger. Analysis of MNTB-evoked miniature events indicates that this strengthening is accompanied by a 2-fold increase in quantal amplitude. Strengthening is not caused by an increase in the probability of release because paired pulse ratios (PPRs) increased from 0.7 in newborn animals to 0.9 around hearing onset, indicating a developmental decrease rather than increase in release probability. In addition, a possible soma-dendritic relocation of MNTB input seems unlikely to underlie their strengthening as indicated by analysis of the rise times of synaptic currents. Taken together, we conclude that the developmental strengthening of MNTB-LSO connections is achieved by a 2-fold increase in quantal size and an 8-fold increase in quantal content.
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