ReviewBiophysical chemistry2010
The molecular origins of the mechanical properties of fibrin.
Review in Biophysical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 86 citations in OpenAlex.
- Fibrin as a Versatile Fibrous Biopolymer.Sub-cellular biochemistry · 2026Review
- Structural Mechanisms of Forced Unfolding of Double-Stranded Fibrin Oligomers.The journal of physical chemistry. B · 2025Article
- Rupture mechanics of blood clot fibrin fibers: A coarse-grained model study.Journal of the mechanics and physics of solids · 2025Article
- Recent Research Progress of Wound Healing Biomaterials Containing Platelet-Rich Plasma.International journal of nanomedicine · 2025Review
- Engineered Recombinant Hagfish Intermediate Filament Proteins: Unraveling Domain Roles in Synthetic Fiber Formation and Mechanics.ACS omega · 2024Article
- Hyperelasticity of blood clots: Bridging the gap between microscopic and continuum scales.Journal of the mechanics and physics of solids · 2024Article
- Mechanical Evaluation of Commercially Available Fibrin Sealants for Cartilage Repair.Cartilage · 2024Article
- Method to obtain a plasma rich in platelet- and plasma-growth factors based on water evaporation.PloS one · 2024Article
- Advances in Fibrin-Based Materials in Wound Repair: A Review.Molecules (Basel, Switzerland) · 2022Review
- Structural control of fibrin bioactivity by mechanical deformation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Regulation of biomaterial implantation-induced fibrin deposition to immunological functions of dendritic cells.Materials today. Bio · 2022Article
- New design to remove leukocytes from platelet-rich plasma (PRP) based on cell dimension rather than density.Bioactive materials · 2021Article
- Changes in the Molecular Characteristics of Bovine and Marine Collagen in the Presence of Proteolytic Enzymes as a Stage Used in Scaffold Formation.Marine drugs · 2021Article
- Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials.Pharmaceutics · 2020Review
- Hydrogel scaffolds based on blood plasma cryoprecipitate and collagen derived from various sources: Structural, mechanical and biological characteristics.Bioactive materials · 2019Article
- Contribution of nascent cohesive fiber-fiber interactions to the non-linear elasticity of fibrin networks under tensile load.Acta biomaterialia · 2019Article
- Abnormal fibrinogen with an Aα 16Arg → Cys substitution is associated with multiple cerebral infarctions.Journal of thrombosis and thrombolysis · 2018Review
- Fibroblast migration correlates with matrix softness. A study in knob-hole engineered fibrin.APL bioengineering · 2018Article
- Biofabrication of injectable fibrin microtissues for minimally-invasive therapies: application of surfactants.Biomedical materials (Bristol, England) · 2018Article
- Controlling Fibrin Network Morphology, Polymerization, and Degradation Dynamics in Fibrin Gels for Promoting Tissue Repair.Methods in molecular biology (Clifton, N.J.) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
When normal blood circulation is compromised by damage to vessel walls, clots are formed at the site of injury. These clots prevent bleeding and support wound healing. To sustain such physiological functions, clots are remarkably extensible and elastic. Fibrin fibers provide the supporting framework of blood clots, and the properties of these fibers underlie the mechanical properties of clots. Recent studies, which examined individual fibrin fibers or cylindrical fibrin clots, have shown that the mechanical properties of fibrin depend on the mechanical properties of the individual fibrin monomers. Within the fibrin monomer, three structures could contribute to these properties: the coiled-coil connectors the folded globular nodules and the relatively unstructured αC regions. Experimental data suggest that each of these structures contributes. Here we review the recent work with a focus on the molecular origins of the remarkable biomechanical properties of fibrin clots.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.