ArticleNeurobiology of aging2012
Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Aging diminishes interlaminar functional connectivity in the mouse cortical V1 and CA1 hippocampal regions.bioRxiv : the preprint server for biology · 2025Article
- Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG.Nature communications · 2024Article
- Inflammaging and Brain Aging.International journal of molecular sciences · 2024Review
- Dynamics of mature myelin.Nature neuroscience · 2024Review
- Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS.Acta neuropathologica · 2024Article
- Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG.bioRxiv : the preprint server for biology · 2024Article
- Adult-onset depletion of sulfatide leads to axonal degeneration with relative myelin sparing.Glia · 2023Article
- Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain.Frontiers in aging neuroscience · 2023Review
- Oligodendroglia heterogeneity in the human central nervous system.Acta neuropathologica · 2022Review
- Oligodendrocytes in the aging brain.Neuronal signaling · 2021Review
- Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?Frontiers in aging neuroscience · 2021Review
- Article
- The effect of age-related risk factors and comorbidities on white matter injury and repair after ischemic stroke.Neurobiology of disease · 2019Review
- Regulation of myelin structure and conduction velocity by perinodal astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Nfasc155H and MAG are specifically susceptible to detergent extraction in the absence of the myelin sphingolipid sulfatide.Neurochemical research · 2013Article
- Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Paranodal permeability in "myelin mutants".Glia · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Paranodal axo-glial junctional complexes anchor the myelin sheath to the axon and breakdown of these complexes presumably facilitates demyelination. Myelin deterioration is also prominent in the aging central nervous system (CNS); however, the stability of the paranodal complexes in the aged CNS has not been examined. Here, we show that transverse bands, prominent components of paranodal junctions, are significantly reduced in the aged CNS; however, the number of paired clusters of both myelin and axonal paranodal proteins is not altered. Ultrastructural analyses also reveal that thicker myelin sheaths display a "piling" of paranodal loops, the cytoplasm-containing sacs that demarcate the paranode. Loops involved in piling are observed throughout the paranode and are not limited to loops positioned in either the nodal- or juxtanodal-most regions. Here, we propose that as myelination continues, previously anchored loops lose their transverse bands and recede away from the axolemma. Newly juxtaposed loops then lose their transverse bands, move laterally to fill in the gap left by the receded loops and finally reform their transverse bands. This paranodal reorganization results in conservation of paranodal length, which may be important in maintaining ion channel spacing and axonal function. Furthermore, we propose that transverse band reformation is less efficient in the aged CNS, resulting in the significant reduction of these junctional components. Although demyelination was not observed, we propose that loss of transverse bands facilitates myelin degeneration and may predispose the aged CNS to a poorer prognosis following a secondary insult.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.