ArticleNanomedicine : nanotechnology, biology, and medicine2011
Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
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- Application of 3D Cell Culture Techniques in Nanotoxicology: How Far Are We?Stem cell reviews and reports · 2026Review
- Fitness related effects of titanium dioxide nanoparticles and glyphosate exposure on Cardiocondyla obscurior.Environmental science and pollution research international · 2026Article
- Sub-15 nm Nanoparticles for Drug Delivery: Emerging Frontiers and Therapeutic Potential.International journal of molecular sciences · 2025Review
- The systemic and local interactions related to titanium implant corrosion and hypersensitivity reactions: a narrative review of the literature.International journal of implant dentistry · 2024Review
- Perturbation of intestinal stem cell homeostasis and radiation enteritis recovery via dietary titanium dioxide nanoparticles.Cell proliferation · 2023Article
- MRC-5 Human Lung Fibroblasts Alleviate the Genotoxic Effect of Fe-N Co-Doped Titanium Dioxide Nanoparticles through an OGG1/2-Dependent Reparatory Mechanism.International journal of molecular sciences · 2023Article
- Mechanisms of regulation of motility of the gastrointestinal tract and the hepatobiliary system under the chronic action of nanocolloids.Scientific reports · 2023Article
- A reliable workflow for improving nanoscale X-ray fluorescence tomographic analysis on nanoparticle-treated HeLa cells.Metallomics : integrated biometal science · 2022Article
- Assessment of TiOMaterials (Basel, Switzerland) · 2022Article
- Intercomparison of radiosensitization induced by gold and iron oxide nanoparticles in human glioblastoma cells irradiated by 6 MV photons.Scientific reports · 2022Article
- Chronic effects of two rutile TiOParticle and fibre toxicology · 2022Article
- Lipid Cubic Systems for Sustained and Controlled Delivery of Antihistamine Drugs.Molecular pharmaceutics · 2021Article
- Development of Multi-Scale X-ray Fluorescence Tomography for Examination of Nanocomposite-Treated Biological Samples.Cancers · 2021Article
- Epidermal SR-A Complexes Are Lipid Raft Based and Promote Nucleic Acid Nanoparticle Uptake.The Journal of investigative dermatology · 2021Article
- Biomaterials for Three-Dimensional Cell Culture: From Applications in Oncology to Nanotechnology.Nanomaterials (Basel, Switzerland) · 2021Review
- Development of FeCancer nanotechnology · 2021Article
- Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine.Nano-micro letters · 2020Review
- Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFeInternational journal of nanomedicine · 2020Article
- Differential Effects of Nano TiO₂ and CeO₂ on Normal Human Lung Epithelial CellsJournal of nanoscience and nanotechnology · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
Nanotechnology has introduced many exciting new tools for the treatment of human diseases. One of the obstacles in its application to that end is the lack of a fundamental understanding of the interaction that occurs between nanoparticles and living cells. This report describes the quantitative analysis of the kinetics and endocytic pathways involved in the uptake of anatase titanium dioxide (TiO(2)) nanoparticles into prostate cancer PC-3M cells. The experiments were performed with TiO(2) nanoconjugates: 6-nm nanoparticles with surface-conjugated fluorescent Alizarin Red S. Results obtained by flow cytometry, fluorescence microscopy, and inductively coupled plasma-mass spectrometry confirmed a complex nanoparticle-cell interaction involving a variety of endocytic mechanisms. The results demonstrated that a temperature, concentration, and time-dependent internalization of the TiO(2) nanoparticles and nanoconjugates occurred via clathrin-mediated endocytosis, caveolin-mediated endocytosis, and macropinocytosis. FROM THE CLINICAL EDITOR: The interaction and uptake of TiO(2) nanoparticles (6-nm) with prostate PC-3M cells was investigated and found to undergo temperature, time, and concentration dependent intracellular transport that was mediated through clathrin pits, caveolae, and macropinocytosis. These results suggest that nanoparticles may widely permeate through tissues and enter almost any active cell through a variety of biological mechanisms, posing both interesting opportunity and possible challenges for systemic use.
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