ArticleCongestive heart failure (Greenwich, Conn.)
Deciphering STAT3 signaling in the heart: plasticity and vascular inflammation.
Article in Congestive heart failure (Greenwich, Conn.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- TNF-α-Induced Upregulation of ADAMTS-8 Expression in SW480 Cells: Implications for Intracellular Signaling Pathways and Transcription Factor Activity.Cell biochemistry and biophysics · 2026Article
- Aqueous extract ofFrontiers in pharmacology · 2023Article
- Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution.Pharmacological reviews · 2020Review
- Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Article
- Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart.JAK-STAT · 2013Review
- LIF and the heart: just another brick in the wall?European cytokine network · 2013Review
- Selenate enhances STAT3 transcriptional activity in endothelial cells: differential actions of selenate and selenite on LIF cytokine signaling and cell viability.Journal of inorganic biochemistry · 2012Article
- Differential STAT3 signaling in the heart: Impact of concurrent signals and oxidative stress.JAK-STAT · 2012Article
- A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury.American journal of physiology. Renal physiology · 2012Article
- Induction of heme oxygenase-1 shifts the balance from proinjury to prosurvival in the placentas of pregnant rats with reduced uterine perfusion pressure.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that plays a critical role in heart development and protection. New developments in understanding its molecular chemistry have revealed the importance of STAT3 in controlling mitochondrial respiration, independent of its function as a transcription factor, and in modulating inflammatory signaling through interactions with other transcription factors and cofactors. The purpose of this article is 2-fold. First, the authors summarize some recent insights into the function of STAT3. Second, the authors seek to illustrate the complexity of targeting a particular cellular protein for therapeutic purposes and the need to consider context when attempting to decipher the role of a particular signaling pathway in the heart. In this case, inflammation, aging, hypertrophy, and heart failure provide new environments that certainly impact on the functioning of STAT3 and on the gene profile linked to its activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.