ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2010
Unresectable pancreatic adenocarcinoma: do we know who survives?
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels.Scientific reports · 2015Article
- McGill Brisbane Symptom Score for patients with resectable pancreatic head adenocarcinoma.World journal of gastroenterology · 2014Article
- Pancreatic cancer and predictors of survival: comparing the CA 19-9/bilirubin ratio with the McGill Brisbane Symptom Score.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2013Article
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9 authors.
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Abstract
backgroundThis study attempts to define clinical predictors of survival in patients with unresectable pancreatic adenocarcinoma (UPA).
methodsA retrospective study of 94 consecutive patients diagnosed with UPA from 2001 to 2006 was performed. Using data for these patients, a symptom score was devised through a forward stepwise Cox proportional hazards model based on four weighted criteria: weight loss of >10% of body weight; pain; jaundice, and smoking. The symptom score was subsequently validated in a distinct cohort of 32 patients diagnosed with UPA in 2007.
resultsIn the original cohort, the overall median survival was 9.0 months (95% confidence interval [CI] 7.6-10.4). This altered to 10.3 months (95% CI 6.1-14.5) in patients with locally advanced disease, and 6.6 months (95% CI 4.2-9.0) in patients with distant metastasis. Median survival was 14.6 months (95% CI 13.1-16.1) in patients with a low symptom (LS) score and 6.3 months (95% CI 4.1-8.5) in patients with a high symptom (HS) score. A total of 73% of LS score patients survived beyond 9 months, compared with only 38% of HS score patients (P<0.001). The discrimination of the LS score was greater than that of any conventional method, including imaging. The validation cohort confirmed the discriminative ability of the symptom score for survival.
conclusionsA simple and clinically meaningful point-based symptom score can successfully predict survival in patients with UPA.
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