Evidence map›Paper›PMID 20887226›Full record

ReviewThe Journal of infectious diseases2010

What infants and breasts can teach us about natural protection from HIV infection.

Grace M Aldrovandi, Louise Kuhn

Abstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. An HIV Vaccine Protective Allele inFrontiers in immunology · 2021
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Immunology of pediatric HIV infection.Immunological reviews · 2013
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Immune approaches for the prevention of breast milk transmission of HIV-1.Advances in experimental medicine and biology · 2012
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Grace M AldrovandiChildrens Hospital Los Angeles, Los Angeles, CA 90027, USA. galdrovandi@chla.usc.edu
Louise Kuhn

Funding

International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) GroupU01AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI JACKSON, J BROOKS · 2006 to 2010
$109.7M
LC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2M
Short Exclusive Breastfeeding to Reduce Postnatal Transmission of HIVR01HD039611 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI THEA, DONALD M · 2000 to 2006
$8.0M
Pathogenesis of Mother to Child Transmission of HIVR01HD040777 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALDROVANDI, GRACE M · 2002 to 2011
$4.4M
Safer Weaning Practices for HIV-infected womenR01HD057617 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2007 to 2011
$2.0M
Oral Transmission of HIV through BreastfeedingR01DE021238 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALDROVANDI, GRACE M, KUHN, LOUISE · 2010 to 2013
$1.7M
NIAID NIH HHS U01 AI068632NIAID NIH HHS UM1 AI106716NIAID NIH HHS UO1 AI068632-01NICHD NIH HHS HD 39611NICHD NIH HHS HD 40777NICHD NIH HHS HD 57161NICHD NIH HHS R01 HD039611NICHD NIH HHS R01 HD040777NICHD NIH HHS R01 HD057617NIDCR NIH HHS R01 DE021238
6 · The paper itself

Abstract

Most individuals exposed to human immunodeficiency virus (HIV), adults and children alike, do not become infected. Understanding the basis of this protection depends on systematically and comprehensively defining factors that determine the infectiousness of the host and the susceptibility of the recipient. Successful transmission depends on the relative balance between infectiousness and susceptibility, both of which are influenced by biologic, behavioral, and environmental factors. In this review, we discuss the advantages and disadvantages of mother‐to‐child HIV transmission as a model in which to elucidate correlates of immune protection.

Indexed as

Breast FeedingAdultFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalPregnancyUnited States

Identifiers

PMID20887226
PMCPMC2951298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.