ArticleBiochemistry2010
Aminoglycoside binding to Oxytricha nova telomeric DNA.
Article in Biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Parallel G-quadruplex recognition by neomycin.Frontiers in chemistry · 2023Article
- Surface Dependent Dual Recognition of a G-quadruplex DNA With Neomycin-Intercalator Conjugates.Frontiers in chemistry · 2020Article
- Discovery of High Affinity Receptors for Dityrosine through Inverse Virtual Screening and Docking and Molecular Dynamics.International journal of molecular sciences · 2018Article
- Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin.Scientific reports · 2017Article
- Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in KChemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Marine Fungi: A Source of Potential Anticancer Compounds.Frontiers in microbiology · 2017Review
- Utilization of chromic polydiacetylene assemblies as a platform to probe specific binding between drug and RNA.RSC advances · 2017Article
- Evidences for Piperine inhibiting cancer by targeting human G-quadruplex DNA sequences.Scientific reports · 2016Article
- Multivalency in the recognition and antagonism of a HIV TAR RNA-TAT assembly using an aminoglycoside benzimidazole scaffold.Organic & biomolecular chemistry · 2016Article
- Influence of linker length in shape recognition of B* DNA by dimeric aminoglycosides.Bioorganic & medicinal chemistry · 2015Article
- Article
- Charge reduction and thermodynamic stabilization of substrate RNAs inhibit RNA editing.PloS one · 2015Article
- A pH Sensitive High-Throughput Assay for miRNA Binding of a Peptide-Aminoglycoside (PA) Library.PloS one · 2015Article
- Multivalent Amino Sugars to Recognize Different TAR RNA Conformations.MedChemComm · 2014Article
- Shape readout of AT-rich DNA by carbohydrates.Biopolymers · 2014Article
- An assay for human telomeric G-quadruplex DNA binding drugs.Bioorganic & medicinal chemistry letters · 2013Article
- Targeting C-myc G-quadruplex: dual recognition by aminosugar-bisbenzimidazoles with varying linker lengths.Molecules (Basel, Switzerland) · 2013Article
- Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.Bioorganic & medicinal chemistry letters · 2013Article
- Dual recognition of the human telomeric G-quadruplex by a neomycin-anthraquinone conjugate.Chemical communications (Cambridge, England) · 2013Article
- A fluorescence-based screen for ribosome binding antibiotics.Analytical biochemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Telomeric DNA sequences have been at the center stage of drug design for cancer treatment in recent years. The ability of these DNA structures to form four-stranded nucleic acid structures, called G-quadruplexes, has been perceived as target for inhibiting telomerase activity vital for the longevity of cancer cells. Being highly diverse in structural forms, these G-quadruplexes are subjects of detailed studies of ligand-DNA interactions of different classes, which will pave the way for logical design of more potent ligands in future. The binding of aminoglycosides was investigated with Oxytricha nova quadruplex forming DNA sequence (GGGGTTTTGGGG)(2). Isothermal titration calorimetry (ITC) determined ligand to quadruplex binding ratio shows 1:1 neomycin:quadruplex binding with association constants (K(a)) ∼ 10(5) M(-1) while paromomycin was found to have a 2-fold weaker affinity than neomycin. The CD titration experiments with neomycin resulted in minimal changes in the CD signal. FID assays, performed to determine the minimum concentration required to displace half of the fluorescent probe bound, showed neomycin as the best of the all aminoglycosides studied for quadruplex binding. Initial NMR footprint suggests that ligand-DNA interactions occur in the wide groove of the quadruplex. Computational docking studies also indicate that aminoglycosides bind in the wide groove of the quadruplex.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.