Evidence map›Paper›PMID 20886276›Full record

ArticleJournal of autism and developmental disorders2010

Using perceptual signatures to define and dissociate condition-specific neural etiology: autism and fragile X syndrome as model conditions.

Armando Bertone, Julie Hanck, Cary Kogan, Avi Chaudhuri, Kim Cornish

Abstract read
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In one paragraph

Article in Journal of autism and developmental disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Armando BertonePerceptual Neuroscience Laboratory for Autism and Developmental Conditions, University of Montreal Center of Excellence for Pervasive Developmental Disorders (CETEDUM), Hôpital Rivière-des-Prairies, 7070 boulevard Perras, Montreal, Quebec, Canada. armando.bertone@umontreal.ca
Julie Hanck
Cary Kogan
Avi Chaudhuri
Kim Cornish

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevelopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In this paper and its companion paper, we propose a method for assessing the functional link between genotype and neural alteration across these target conditions by comparing their perceptual signatures. In the present paper, we discuss how such signatures can be used to (1) define and differentiate various aspects of neural functioning in autism and FXS, and subsequently, (2) to infer candidate causal (genetic) mechanisms based on such signatures (see companion paper, this issue).

Indexed as

Autistic DisorderBrainFragile X SyndromeHumansNerve NetPerceptionPhenotype

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.