ArticlePflugers Archiv : European journal of physiology2010
The large-conductance ion channels in the nuclear envelope of central neurons.
Article in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- BK in Double-Membrane Organelles: A Biophysical, Pharmacological, and Functional Survey.Frontiers in physiology · 2021Review
- Editorial: Post-translational Modifications in Plant Nuclear Signaling: Novel Insights Into Responses to Environmental Changes.Frontiers in plant science · 2019Article
- Calcium- and voltage-gated BK channels in vascular smooth muscle.Pflugers Archiv : European journal of physiology · 2018Review
- Monovalent cationic channel activity in the inner membrane of nuclei from skeletal muscle fibers.Biophysical journal · 2014Article
- Endoplasmic reticulum membrane potassium channel dysfunction in high fat diet induced stress in rat hepatocytes.EXCLI journal · 2014Article
- A role for phosphoinositides in regulating plant nuclear functions.Frontiers in plant science · 2012Article
- Identification and quantification of full-length BK channel variants in the developing mouse cochlea.Journal of neuroscience research · 2011Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Patch-clamp recording from the nuclear envelope of a variety of cells has revealed the presence of large-conductance ion channels. It has been argued that these channels are the channels of the nuclear pore complex for passive nucleo-cytoplasmic diffusion. Here we studied spontaneously active large-conductance ion channels in the nuclear envelope of cerebellar Purkinje neurons. These channels were selective for small monovalent cations and demonstrated clear voltage dependence. The channels recorded from the outer nuclear membrane were inhibited by positive potentials whereas the channels from the inner nuclear membrane were inhibited by negative potentials in the patch pipette. These data are compatible with the localization of the channels to the nuclear membrane. We conclude that these channels are not a part of the nuclear pore complex but provide a route for exchange of monovalent cations between the perinuclear space and the cytoplasm and the nucleoplasm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.