ArticlePloS one2010
Metabolomic and functional genomic analyses reveal varietal differences in bioactive compounds of cooked rice.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 84 citations in OpenAlex.
- Heat-stabilised rice bran consumption by colorectal cancer survivors modulates stool metabolite profiles and metabolic networks: a randomised controlled trial.The British journal of nutrition · 2017Trial
- Genetic Divergence and Functional Significance of Bioactive Compounds in Rice and Barley: Implications for Biofortification and Human Health.International journal of molecular sciences · 2025Review
- Traditional Mexican Food: Phenolic Content and Public Health Relationship.Foods (Basel, Switzerland) · 2023Article
- Antioxidant, Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates.Foods (Basel, Switzerland) · 2020Article
- Gas Chromatography-Mass Spectrometry and Single Nucleotide Polymorphism-Genotype-By-Sequencing Analyses Reveal the Bean Chemical Profiles and Relatedness ofPlants (Basel, Switzerland) · 2019Article
- Article
- Fermentation Biotechnology Applied to Cereal Industry By-Products: Nutritional and Functional Insights.Frontiers in nutrition · 2019Review
- Genome-Wide Association Study Using Historical Breeding Populations Discovers Genomic Regions Involved in High-Quality Rice.The plant genome · 2018Article
- Review
- Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene⁻Bran Metabolite Relationships.Metabolites · 2018Article
- Impact of Prebiotics on Poultry Production and Food Safety.The Yale journal of biology and medicine · 2018Review
- Metabolomics and Ionomics of Potato Tuber Reveals an Influence of Cultivar and Market Class on Human Nutrients and Bioactive Compounds.Frontiers in nutrition · 2018Article
- Rice Bran Metabolome Contains Amino Acids, Vitamins & Cofactors, and Phytochemicals with Medicinal and Nutritional Properties.Rice (New York, N.Y.) · 2017Article
- Metabolomic analysis of pathways related to rice grain chalkiness by a notched-belly mutant with high occurrence of white-belly grains.BMC plant biology · 2017Article
- Integrated metabolomics and phytochemical genomics approaches for studies on rice.GigaScience · 2016Review
- Prospects of breeding high-quality rice using post-genomic tools.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Review
- The quest for tolerant varieties: the importance of integrating "omics" techniques to phenotyping.Frontiers in plant science · 2015Review
- Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism.Nature genetics · 2014Article
- Metabolic variation between japonica and indica rice cultivars as revealed by non-targeted metabolomics.Scientific reports · 2014Article
- Rice antioxidants: phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid.Food science & nutrition · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Emerging evidence supports that cooked rice (Oryza sativa L.) contains metabolites with biomedical activities, yet little is known about the genetic diversity that is responsible for metabolite variation and differences in health traits. Metabolites from ten diverse varieties of cooked rice were detected using ultra performance liquid chromatography coupled to mass spectrometry. A total of 3,097 compounds were detected, of which 25% differed among the ten varieties. Multivariate analyses of the metabolite profiles showed that the chemical diversity among the varieties cluster according to their defined subspecies classifications: indica, japonica, and aus. Metabolite-specific genetic diversity in rice was investigated by analyzing a collection of single nucleotide polymorphisms (SNPs) in genes from biochemical pathways of nutritional importance. Two classes of bioactive compounds, phenolics and vitamin E, contained nonsynonymous SNPs and SNPs in the 5' and 3' untranslated regions for genes in their biosynthesis pathways. Total phenolics and tocopherol concentrations were determined to examine the effect of the genetic diversity among the ten varieties. Per gram of cooked rice, total phenolics ranged from 113.7 to 392.6 µg (gallic acid equivalents), and total tocopherols ranged between 7.2 and 20.9 µg. The variation in the cooked rice metabolome and quantities of bioactive components supports that the SNP-based genetic diversity influenced nutritional components in rice, and that this approach may guide rice improvement strategies for plant and human health.
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