ArticlePloS one2010
Global microRNA characterization reveals that miR-103 is involved in IGF-1 stimulated mouse intestinal cell proliferation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- The regulation of LRPs by miRNAs in cancer: influencing cancer characteristics and responses to treatment.Cancer cell international · 2025Review
- Astrocytic IGF-1 and IGF-1R Orchestrate Mitophagy in Traumatic Brain Injury via Exosomal miR-let-7e.Oxidative medicine and cellular longevity · 2022Article
- miR-1207-5p Can Contribute to Dysregulation of Inflammatory Response in COVID-19Frontiers in cellular and infection microbiology · 2020Article
- MicroRNA-103a regulates sodium-dependent vitamin C transporter-1 expression in intestinal epithelial cells.The Journal of nutritional biochemistry · 2019Article
- Inhibition of microRNA-103a inhibits the activation of astrocytes in hippocampus tissues and improves the pathological injury of neurons of epilepsy rats by regulating BDNF.Cancer cell international · 2019Article
- MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.Frontiers in immunology · 2018Article
- MicroRNA profiling of dogs with transitional cell carcinoma of the bladder using blood and urine samples.BMC veterinary research · 2017Article
- Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects.Arthritis research & therapy · 2017Article
- miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis.Oncotarget · 2017Article
- DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma.Oncotarget · 2016Article
- IGF-1 protects tubular epithelial cells during injury via activation of ERK/MAPK signaling pathway.Scientific reports · 2016Article
- Chicken gga-miR-103-3p Targets CCNE1 and TFDP2 and Inhibits MDCC-MSB1 Cell Migration.G3 (Bethesda, Md.) · 2016Article
- MicroRNA-103a-3p controls proliferation and osteogenic differentiation of human adipose tissue-derived stromal cells.Experimental & molecular medicine · 2015Article
- Insulin-like growth factor-1 endues monocytes with immune suppressive ability to inhibit inflammation in the intestine.Scientific reports · 2015Article
- Characterization of microRNA expression profiles in Leishmania-infected human phagocytes.Parasite immunology · 2015Article
- MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells.RNA (New York, N.Y.) · 2014Article
- Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs.PloS one · 2014Article
- Translational repression of SLC26A3 by miR-494 in intestinal epithelial cells.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity.Molecular cancer research : MCR · 2013Article
- CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.The Journal of cell biology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs play extensive roles in cellular development. Analysis of the microRNA expression pattern during intestinal cell proliferation in early life is likely to unravel molecular mechanisms behind intestinal development and have implications for therapeutic intervention. In this study, we isolated mouse intestinal crypt cells, examined the differences in microRNA expression upon IGF-1 stimulated proliferation and identified miR-103 as a one of the key regulators. Mouse intestinal crypt cells were cultured and treated with IGF-1 for 24 h. MicroRNA microarray showed that multiple microRNAs are regulated by IGF-1, and miR-103 was the most sharply down-regulated. Expression of miR-103 in mouse intestinal crypt cells was confirmed by real-time Q-PCR. Sequence analyses showed that, among the 1040 predicted miR-103 target genes, CCNE1, CDK2, and CREB1 contain complementary sequences to the miR-103 seed region that are conserved between human and mouse. We further demonstrated that miR-103 controls the expression level of these three genes in mouse crypt cells by luciferase assay and immunoblotting assay. Taken together, our data suggest that in mouse intestinal crypt cells, miR-103 is part of the G1/S transition regulatory network, which targets CCNE1, CDK2, and CREB1 during IGF-1 stimulated proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.