Trial reportPloS one2010
Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both?
Trial report in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00169351 (National Gilles De La Tourette Study Group), which is not on this map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
National Gilles De La Tourette Study Group
Who cites it
40 citing papers in PubMed.
- "Just Right" Perceptions and Obsessive-Compulsive Symptoms in Tourette Syndrome and Chronic Tic Disorder: Implications for Tourettic Obsessive-Compulsive Disorder.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026Article
- Striking long-term beneficial effects of single dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming.Molecular psychiatry · 2025Article
- Chronic Tic Disorders in Youth: Clinical Phenotypes and Response to Pharmacological Treatment with Aripiprazole.Children (Basel, Switzerland) · 2024Article
- Striking Long Term Beneficial Effects of Single Dose Psilocybin and Psychedelic Mushroom Extract in the SAPAP3 Rodent Model of OCD-Like Excessive Self-Grooming.bioRxiv : the preprint server for biology · 2024Article
- Striatal insights: a cellular and molecular perspective on repetitive behaviors in pathology.Frontiers in cellular neuroscience · 2024Review
- The Sapap3Translational psychiatry · 2023Article
- The Cerebellum in Drug-naive Children with Tourette Syndrome and Obsessive-Compulsive Disorder.Cerebellum (London, England) · 2022Article
- European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment.European child & adolescent psychiatry · 2022Review
- Reduced Axon Calibre in the Associative Striatum of theBrain sciences · 2021Article
- A Comprehensive Review of Tic Disorders in Children.Journal of clinical medicine · 2021Review
- Challenges in the Diagnosis and Assessment in Patients with Tourette Syndrome and Comorbid Obsessive-Compulsive Disorder.Neuropsychiatric disease and treatment · 2021Review
- Clinical Features That Evoke the Concept of Disinhibition in Tourette Syndrome.Frontiers in psychiatry · 2020Review
- Article
- Clinical Aspects of Premonitory Urges in Patients with Tourette's Disorder.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2019Review
- Association of Rare Genetic Variants in Opioid Receptors with Tourette Syndrome.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Article
- Tourette syndrome: a disorder of the social decision-making network.Brain : a journal of neurology · 2018Review
- Bridging the Great Divide: What Can Neurology Learn From Psychiatry?The Journal of neuropsychiatry and clinical neurosciences · 2018Article
- Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinalTranslational psychiatry · 2017Article
- Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome.The American journal of psychiatry · 2017Article
- Neurobiology of the Premonitory Urge in Tourette's Syndrome: Pathophysiology and Treatment Implications.The Journal of neuropsychiatry and clinical neurosciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRepetitive behaviours (RB) in patients with Gilles de la Tourette syndrome (GTS) are frequent. However, a controversy persists whether they are manifestations of obsessive-compulsive disorder (OCD) or correspond to complex tics.
methods166 consecutive patients with GTS aged 15-68 years were recruited and submitted to extensive neurological, psychiatric and psychological evaluations. RB were evaluated by the YBOCS symptom checklist and Mini International Neuropsychiatric Interview (M.I.N.I), and classified on the basis of a semi-directive psychiatric interview as compulsions or tics.
resultsRB were present in 64.4% of patients with GTS (107/166) and categorised into 3 major groups: a 'tic-like' group (24.3%-40/166) characterised by RB such as touching, counting, 'just right' and symmetry searching; an 'OCD-like' group (20.5%-34/166) with washing and checking rituals; and a 'mixed' group (13.2%-22/166) with both 'tics-like' and 'OCD-like' types of RB present in the same patient. In 6.3% of patients, RB could not be classified into any of these groups and were thus considered 'undetermined'.
conclusionsThe results confirm the phenomenological heterogeneity of RB in GTS patients and allows to distinguish two types: tic-like behaviours which are very likely an integral part of GTS; and OCD-like behaviours, which can be considered as a comorbid condition of GTS and were correlated with higher score of complex tics, neuroleptic and SSRIs treatment frequency and less successful socio-professional adaptation. We suggest that a meticulous semiological analysis of RB in GTS patients will help to tailor treatment and allow to better classify patients for future pathophysiologic studies.
trial registrationClinicalTrials.gov NCT00169351.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.