ArticlePloS one2010
Calcium sets the physiological value of the dominant time constant of saturated mouse rod photoresponse recovery.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina.Cellular and molecular life sciences : CMLS · 2023Article
- An Ex Vivo Electroretinographic Apparatus for the mL-Scale Testing of Drugs to One Day and Beyond.International journal of molecular sciences · 2023Article
- Ex vivo electroretinograms made easy: performing ERGs using 3D printed components.The Journal of physiology · 2020Article
- Article
- Investigating the CaScientific reports · 2018Article
- Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors.The Journal of biological chemistry · 2018Article
- A Novel Method for Mouse Retinal Temperature Determination Based on ERG Photoresponses.Annals of biomedical engineering · 2017Article
- Voltage-sensitive conductances increase the sensitivity of rod photoresponses following pigment bleaching.The Journal of physiology · 2017Article
- Rhodopsin and Melanopsin Contributions to the Early Redilation Phase of the Post-Illumination Pupil Response (PIPR).PloS one · 2016Article
- A novel Ca2+-feedback mechanism extends the operating range of mammalian rods to brighter light.The Journal of general physiology · 2015Article
- Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina.Cell communication and signaling : CCS · 2014Article
- Transretinal ERG recordings from mouse retina: rod and cone photoresponses.Journal of visualized experiments : JoVE · 2012Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rate-limiting step that determines the dominant time constant (τ(D)) of mammalian rod photoresponse recovery is the deactivation of the active phosphodiesterase (PDE6). Physiologically relevant Ca(2+)-dependent mechanisms that would affect the PDE inactivation have not been identified. However, recently it has been shown that τ(D) is modulated by background light in mouse rods. METHODOLOGY/PRINCIPAL
findingsWe used ex vivo ERG technique to record pharmacologically isolated photoreceptor responses (fast PIII component). We show a novel static effect of calcium on mouse rod phototransduction: Ca(2+) shortens the dominant time constant (τ(D)) of saturated photoresponse recovery, i.e., when extracellular free Ca(2+) is decreased from 1 mM to ∼25 nM, the τ(D) is reversibly increased ∼1.5-2-fold.
conclusionsWe conclude that the increase in τ(D) during low Ca(2+) treatment is not due to increased [cGMP], increased [Na(+)] or decreased [ATP] in rod outer segment (ROS). Also it cannot be due to protein translocation mechanisms. We suggest that a Ca(2+)-dependent mechanism controls the life time of active PDE.
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