ArticleHFSP journal2010
Spatiotemporal organization of Ca dynamics: a modeling-based approach.
Article in HFSP journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed.
- Reinforcing Interdisciplinary Collaborations to Unravel the Astrocyte "Calcium Code".Journal of molecular neuroscience : MN · 2022Review
- Histamine activates an intracellular CaFrontiers in cell and developmental biology · 2022Article
- Buffering and total calcium levels determine the presence of oscillatory regimes in cardiac cells.PLoS computational biology · 2020Article
- Automated Intracellular Calcium Profiles Extraction from Endothelial Cells Using Digital Fluorescence Images.International journal of molecular sciences · 2018Article
- A Bayesian approach to modelling heterogeneous calcium responses in cell populations.PLoS computational biology · 2017Article
- Diversity of Evoked Astrocyte CaFrontiers in systems neuroscience · 2017Article
- Reproducibility and Comparability of Computational Models for Astrocyte Calcium Excitability.Frontiers in neuroinformatics · 2017Article
- Interplay Between Intracellular Ca(2+) Oscillations and Ca(2+)-stimulated Mitochondrial Metabolism.Scientific reports · 2016Article
- Modulation of elementary calcium release mediates a transition from puffs to waves in an IP3R cluster model.PLoS computational biology · 2015Article
- Modelling the transition from simple to complex Ca²⁺ oscillations in pancreatic acinar cells.Journal of biosciences · 2014Article
- Towards the Physics of Calcium Signalling in Plants.Plants (Basel, Switzerland) · 2013Review
- Interdisciplinary approaches to calcium dynamics and secretory processes in cells.HFSP journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium is a ubiquitous second messenger that mediates vital physiological responses such as fertilization, secretion, gene expression, or apoptosis. Given this variety of processes mediated by Ca(2+), these signals are highly organized both in time and space to ensure reliability and specificity. This review deals with the spatiotemporal organization of the Ca(2+) signaling pathway in electrically nonexcitable cells in which InsP(3) receptors are by far the most important Ca(2+) channels. We focus on the aspects of this highly regulated dynamical system for which an interplay between experiments and modeling is particularly fruitful. In particular, the importance of the relative densities of the different InsP(3) receptor subtypes will be discussed on the basis of a modeling approach linking the steady-state behaviors of these channels in electrophysiological experiments with their behavior in a cellular environment. Also, the interplay between InsP(3) metabolism and Ca(2+) oscillations will be considered. Finally, we discuss the relationships between stochastic openings of the Ca(2+) releasing channels at the microscopic level and the coordinated, regular behavior observed at the whole cell level on the basis of a combined experimental and modeling approach.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.