ArticleNature cell biology2010
Turning down the volume on transcriptional noise.
Article in Nature cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA feedback.Scientific reports · 2020Article
- Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope.Molecular biology of the cell · 2018Article
- Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability.Protein science : a publication of the Protein Society · 2018Review
- Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.RNA (New York, N.Y.) · 2015Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
Transcriptional noise has an important role in generating diversity in cellular populations that are seemingly identical. As this noise stems from the inherent stochasticity of gene expression, it has been unclear whether it is directly controlled. Dig1, a regulator of the budding yeast mating pathway, is now shown to prevent transcriptional noise by regulating the spatial organization of downstream gene targets.
Indexed as
Identifiers
20885421What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.