ArticleBlood2010
Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells.
Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Weak SLP-76/PLC-γ1 interaction fine-tunes T cell receptor signal strength to optimize T cell responsiveness.Nature communications · 2026Article
- Weak SLP-76-PLC-γ1 interaction in the LAT-nucleated multi-protein complex fine-tunes TCR signal strength to optimize T cell responsiveness.bioRxiv : the preprint server for biology · 2025Article
- Strategies to Address Chimeric Antigen Receptor Tonic Signaling.Molecular cancer therapeutics · 2018Review
- Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma.Frontiers in immunology · 2016Article
- TCR ITAM multiplicity is required for the generation of follicular helper T-cells.Nature communications · 2015Article
- Regulatory T cells require TCR signaling for their suppressive function.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- TCR Signaling in T Cell Memory.Frontiers in immunology · 2015Review
- Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection.Current immunology reviews · 2013Article
- Diacylglycerol kinases: regulated controllers of T cell activation, function, and development.International journal of molecular sciences · 2013Review
- The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Dynamics of CD4(+) T cell responses against Listeria monocytogenes.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Homeostatic division is not necessary for antigen-specific CD4+ memory T cell persistence.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- TCR signaling requirements for activating T cells and for generating memory.Cellular and molecular life sciences : CMLS · 2012Review
- Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.European journal of immunology · 2011Article
- T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.Blood · 2010Article
- The role of interleukin-21 in HIV infection.Cytokine & growth factor reviewsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The requirements for tonic T-cell receptor (TCR) signaling in CD8(+) memory T-cell generation and homeostasis are poorly defined. The SRC homology 2 (SH2)-domain-containing leukocyte protein of 76 kDa (SLP-76) is critical for proximal TCR-generated signaling. We used temporally mediated deletion of SLP-76 to interrupt tonic and activating TCR signals after clearance of the lymphocytic choriomeningitis virus (LCMV). SLP-76-dependent signals are required during the contraction phase of the immune response for the normal generation of CD8 memory precursor cells. Conversely, LCMV-specific memory CD8 T cells generated in the presence of SLP-76 and then acutely deprived of TCR-mediated signals persist in vivo in normal numbers for more than 40 weeks. Tonic TCR signals are not required for the transition of the memory pool toward a central memory phenotype, but the absence of SLP-76 during memory homeostasis substantially alters the kinetics. Our data are consistent with a model in which tonic TCR signals are required at multiple stages of differentiation, but are dispensable for memory CD8 T-cell persistence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.