ArticleThe Plant cell2010
Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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87 citing papers in PubMed, 170 citations in OpenAlex.
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- Genome-wide identification and gene expression pattern analysis of the carotenoid cleavage oxygenase gene family in Fagopyrum tataricum.BMC plant biology · 2025Article
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- A structural and functional model for alkene dioxygenases.Journal of inorganic biochemistry · 2025Article
- An ABA biosynthesis enzyme gene OsNCED4 regulates NaCl and cold stress tolerance in rice.Scientific reports · 2024Article
- Identification and Expression Profile ofInternational journal of molecular sciences · 2024Article
- The Functional Characteristics and Soluble Expression of SaffronInternational journal of molecular sciences · 2023Article
- Comparison of Bioactive Compounds and Antioxidant Activities in Differentially PigmentedMolecules (Basel, Switzerland) · 2023Article
- Nuclear Resonance Vibrational Spectroscopy Definition of Peroxy Intermediates in Catechol Dioxygenases: Factors that Determine Extra- versus Intradiol Cleavage.Journal of the American Chemical Society · 2023Article
- Natural overexpression of CAROTENOID CLEAVAGE DIOXYGENASE 4 in tomato alters carotenoid flux.Plant physiology · 2023Article
- Insights into the Genes Involved in ABA Biosynthesis and Perception during Development and Ripening of the Chilean Strawberry Fruit.International journal of molecular sciences · 2023Article
- Characteristics of a new carotenoid cleavage dioxygenase NtCCD10 derived from Nicotiana tabacum.Planta · 2022Article
- Overexpression of Sweet Potato Carotenoid Cleavage Dioxygenase 4 (International journal of molecular sciences · 2022Article
- Retinal pigment epithelium 65 kDa protein (RPE65): An update.Progress in retinal and eye research · 2022Review
- Identification, In Silico Characterization, and Differential Expression Profiles of Carotenoid, Xanthophyll, Apocarotenoid Biosynthetic Pathways Genes, and Analysis of Carotenoid and Xanthophyll Accumulation inInternational journal of molecular sciences · 2022Article
27 more citing papers are in PubMed but not listed here.
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9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The key regulatory step in the biosynthesis of abscisic acid (ABA), a hormone central to the regulation of several important processes in plants, is the oxidative cleavage of the 11,12 double bond of a 9-cis-epoxycarotenoid. The enzyme viviparous14 (VP14) performs this cleavage in maize (Zea mays), making it a target for the rational design of novel chemical agents and genetic modifications that improve plant behavior through the modulation of ABA levels. The structure of VP14, determined to 3.2-Å resolution, provides both insight into the determinants of regio- and stereospecificity of this enzyme and suggests a possible mechanism for oxidative cleavage. Furthermore, mutagenesis of the distantly related CCD1 of maize shows how the VP14 structure represents a template for all plant carotenoid cleavage dioxygenases (CCDs). In addition, the structure suggests how VP14 associates with the membrane as a way of gaining access to its membrane soluble substrate.
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