ArticleClinical journal of the American Society of Nephrology : CJASN2011
Serum creatinine levels are significantly influenced by renal size in the normal pediatric population.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Short-term effects of rituximab in children with steroid- and calcineurin-dependent nephrotic syndrome: a randomized controlled trial.Clinical journal of the American Society of Nephrology : CJASN · 2011Trial
- [Dietary secoisolariciresinol diglucoside alleviates chronic kidney disease in offspring rats caused by maternal trans-fatty acid exposure by regulating the Bcl-2/Bax/caspase-3 signaling axis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Kidney shape statistical analysis: associations with disease and anthropometric factors.BMC nephrology · 2023Article
- Role of foetal kidney size on kidney function in childhood: the born in bradford cohort renal study.BMC nephrology · 2023Article
- The old becomes new: advances in imaging techniques to assess nephron mass in children.Pediatric nephrology (Berlin, Germany) · 2021Review
- Are low birth weight neonates at risk for suboptimal renal growth and function during infancy?BMC nephrology · 2016Article
- A step forward towards accurately assessing glomerular filtration rate in newborns.Pediatric nephrology (Berlin, Germany) · 2015Article
- Childhood kidney outcomes in relation to fetal blood flow and kidney size.Journal of the American Society of Nephrology : JASN · 2014Article
- Kidney size and function in a multi-ethnic population-based cohort of school-age children.Pediatric nephrology (Berlin, Germany) · 2014Article
- Left ventricular mass: correlation with fatness, hemodynamics and renal morphology.Polish journal of radiology · 2014Article
- Renal growth in isolated methylmalonic acidemia.Genetics in medicine : official journal of the American College of Medical Genetics · 2013Article
- Race-specific relationship of birth weight and renal function among healthy young children.Pediatric nephrology (Berlin, Germany) · 2012Article
- Length and volume of morphologically normal kidneys in korean children: ultrasound measurement and estimation using body size.Korean journal of radiologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesClinical and experimental data have shown that differences in nephron endowment result in differences in renal mass and predisposition to chronic renal failure, hypertension, and proteinuria. We hypothesized that a significant proportion of the variance in GFR, as estimated by serum creatinine, is attributable to differences in renal size in normal children. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A total of 1748 normal renal ultrasounds that were performed in children older than 6 months were reviewed. For each ultrasound, serum creatinine, serum blood urea nitrogen, and systolic and diastolic office BP were recorded. Renal size was evaluated as a function of renal length and thickness. All data were normalized for height, weight, age, and gender.
resultsWhen expressed as SD scores, a significant correlation was found between kidney size and serum creatinine (P < 0.0001) and between kidney size and serum blood urea nitrogen (P < 0.002). When dividing kidney size data per quintiles, a difference of 0.51 SD score in serum creatinine was observed between the lowest and highest quintile. No significant correlation was found with office BP measurements.
conclusionsThese data show that, even in the normal pediatric population, differences in renal function are significantly explained by differences in renal mass. Methodologic limitations of this study are likely to underestimate this relationship.
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