Evidence map›Paper›PMID 20884764›Full record

ArticleJournal of neurophysiology2010

Late-expiratory activity: emergence and interactions with the respiratory CpG.

Yaroslav I Molkov, Ana P L Abdala, Bartholomew J Bacak, Jeffrey C Smith, Julian F R Paton, Ilya A Rybak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
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  12. Neurogenic hypertension and the secrets of respiration.American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Review
  13. Article
  14. Article
  15. Computational models of the neural control of breathing.Wiley interdisciplinary reviews. Systems biology and medicine · 2017
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yaroslav I MolkovDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Ana P L Abdala
Bartholomew J Bacak
Jeffrey C Smith
Julian F R Paton
Ilya A Rybak
Drexel University · USUniversity of Bristol · GBNational Institute of Neurological Disorders and Stroke · US

Funding

Multi-Scale Models of Neural Mechanisms Controlling Breathing in MammalsZIANS003108 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SMITH, JEFFREY C · 2009 to 2023
$7.5M
CRCNS: State dependent neural mechanisms for respiratory pattern generationR01NS057815 · NINDS · DREXEL UNIVERSITY · PI RYBAK, ILYA A · 2006 to 2010
$1.4M
Intramural NIH HHSNINDS NIH HHS R01 NS-057815
6 · The paper itself

Abstract

The respiratory rhythm and motor pattern are hypothesized to be generated by a brain stem respiratory network with a rhythmogenic core consisting of neural populations interacting within and between the pre-Bötzinger (pre-BötC) and Bötzinger (BötC) complexes and controlled by drives from other brain stem compartments. Our previous large-scale computational model reproduced the behavior of this network under many different conditions but did not consider neural oscillations that were proposed to emerge within the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) and drive preinspiratory (or late-expiratory, late-E) discharges in the abdominal motor output. Here we extend the analysis of our previously published data and consider new data on the generation of abdominal late-E activity as the basis for extending our computational model. The extended model incorporates an additional late-E population in RTN/pFRG, representing a source of late-E oscillatory activity. In the proposed model, under normal metabolic conditions, this RTN/pFRG oscillator is inhibited by BötC/pre-BötC circuits, and the late-E oscillations can be released by either hypercapnia-evoked activation of RTN/pFRG or by hypoxia-dependent suppression of RTN/pFRG inhibition by BötC/pre-BötC. The proposed interactions between BötC/pre-BötC and RTN/pFRG allow the model to reproduce several experimentally observed behaviors, including quantal acceleration of abdominal late-E oscillations with progressive hypercapnia and quantal slowing of phrenic activity with progressive suppression of pre-BötC excitability, as well as to predict a release of late-E oscillations by disinhibition of RTN/pFRG under normal conditions. The extended model proposes mechanistic explanations for the emergence of RTN/pFRG oscillations and their interaction with the brain stem respiratory network.

Indexed as

Models, NeurologicalAnimalsBrain StemElectrophysiologyExcitatory Amino Acid AntagonistsExhalationNeuronsRatsRespirationRiluzoleSpinal CordExcitatory Amino Acid AntagonistsRiluzole

Identifiers

PMID20884764
PMCPMC2997033
OpenAlexW2135965580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.