ArticleGenome biology and evolution2010
Evolutionary analysis and expression profiling of zebra finch immune genes.
Article in Genome biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
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- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Genomic associations with poxvirus across divergent island populations in Berthelot's pipit.Molecular ecology · 2022Article
- Article
- Tissue-specific expression profiles and positive selection analysis in the tree swallow (Tachycineta bicolor) using a de novo transcriptome assembly.Scientific reports · 2019Article
- Balancing Selection Drives the Maintenance of Genetic Variation in Drosophila Antimicrobial Peptides.Genome biology and evolution · 2019Article
- Transcriptomic analysis of immune response to bacterial lipopolysaccharide in zebra finch (Taeniopygia guttata).BMC genomics · 2019Article
- Molecular evolution in immune genes across the avian tree of life.Parasitology open · 2019Article
- Genome Sequence of Peacock Reveals the Peculiar Case of a Glittering Bird.Frontiers in genetics · 2018Article
- Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation.Genome biology and evolution · 2016Article
- Drift, not selection, shapes toll-like receptor variation among oceanic island populations.Molecular ecology · 2015Article
- Using genomics to characterize evolutionary potential for conservation of wild populations.Evolutionary applications · 2014Article
- Defense genes missing from the flight division.Developmental and comparative immunology · 2013Review
- Characteristics of MHC class I genes in house sparrows Passer domesticus as revealed by long cDNA transcripts and amplicon sequencing.Journal of molecular evolution · 2013Article
- Structural and functional annotation of the porcine immunome.BMC genomics · 2013Article
- Transcriptome sequencing of black grouse (Tetrao tetrix) for immune gene discovery and microsatellite development.Open biology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Genes of the immune system are generally considered to evolve rapidly due to host-parasite coevolution. They are therefore of great interest in evolutionary biology and molecular ecology. In this study, we manually annotated 144 avian immune genes from the zebra finch (Taeniopygia guttata) genome and conducted evolutionary analyses of these by comparing them with their orthologs in the chicken (Gallus gallus). Genes classified as immune receptors showed elevated d(N)/d(S) ratios compared with other classes of immune genes. Immune genes in general also appear to be evolving more rapidly than other genes, as inferred from a higher d(N)/d(S) ratio compared with the rest of the genome. Furthermore, ten genes (of 27) for which sequence data were available from at least three bird species showed evidence of positive selection acting on specific codons. From transcriptome data of eight different tissues, we found evidence for expression of 106 of the studied immune genes, with primary expression of most of these in bursa, blood, and spleen. These immune-related genes showed a more tissue-specific expression pattern than other genes in the zebra finch genome. Several of the avian immune genes investigated here provide strong candidates for in-depth studies of molecular adaptation in birds.
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