ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2010
Pneumonia following antipsychotic prescriptions in electronic health records: a patient safety concern?
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Biological substantiation of antipsychotic-associated pneumonia: Systematic literature review and computational analyses.PloS one · 2017Pooled it
- Choice of observational study design impacts on measurement of antipsychotic risks in the elderly: a systematic review.BMC medical research methodology · 2012Pooled it
- Anti-psychotic therapeutics modify gut microbial metabolism and modulate susceptibility to gastrointestinal infection in mice.bioRxiv : the preprint server for biology · 2026Article
- Antipsychotic Medication Use Among Older Adults Following Infection-Related Hospitalization.JAMA network open · 2023Article
- Psychotropic Drug-Associated Pneumonia in Older Adults.Drugs & aging · 2020Review
- Antipsychotics and the Risk of Aspiration Pneumonia in Individuals Hospitalized for Nonpsychiatric Conditions: A Cohort Study.Journal of the American Geriatrics Society · 2017Article
- Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2015Article
- Longitudinal medical records as a complement to routine drug safety signal analysis.Pharmacoepidemiology and drug safety · 2015Article
- Are the safety profiles of antipsychotic drugs used in dementia the same? An updated review of observational studies.Drug safety · 2014Review
- Detecting potential adverse reactions of sulpiride in schizophrenic patients by prescription sequence symmetry analysis.PloS one · 2014Article
- vigiGrade: a tool to identify well-documented individual case reports and highlight systematic data quality issues.Drug safety · 2014Article
- Antipsychotic drug use and community-acquired pneumonia.Current infectious disease reports · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn screening the Intercontinental Medical Statistics (IMS) Health Disease Analyzer database of GP records from the UK, an increased registration of pneumonia subsequent to the prescription of some antipsychotic medicines was identified.
aimTo investigate the temporal pattern between antipsychotic prescriptions and pneumonia with respect to age, type of pneumonia and other chest infections, and antipsychotic class. DESIGN OF STUDY: Self-controlled cohort analysis.
settingElectronic health records from the UK IMS Health Disease Analyzer database.
methodThree groups of pneumonia-related International Classification of Diseases (ICD)-10 terms and prescriptions of atypical and conventional antipsychotic medicines were studied. Separate analyses were carried out for patients aged 65 years. The observed rate of pneumonia terms registered in different time periods in connection to antipsychotic prescriptions was contrasted to the overall rate of pneumonia terms relative to prescriptions of other drugs in the same dataset.
resultsIn patients aged ≥ 65 years, an increased registration of a group of terms defined as 'acute chest infections', after atypical antipsychotic prescriptions, was identified. The corresponding increase after conventional antipsychotic prescriptions was much smaller. Bronchopneumonia had a striking increase after both atypical and conventional antipsychotic prescriptions, and was commonly recorded with fatal outcome. Few registrations of hypostatic pneumonia were noted. Patients aged <65 years did not have a higher rate of acute chest infections after receiving antipsychotic prescriptions.
conclusionThe consistent pattern of an increased rate of chest infections after atypical antipsychotic prescriptions in older people seen in this outpatient study, together with the higher risk shown in a previous study on hospitalised patients, suggests a causal relationship. This is of importance since bronchopneumonia seems highly linked to fatal outcome. In the absence of a mechanism, further investigation of the role of antipsychotics in older people is needed.
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