Evidence map›Paper›PMID 20882949›Full record

ReviewThe Journal of organic chemistry2010

Frontiers and opportunities in chemoenzymatic synthesis.

Jonathan D Mortison, David H Sherman

Abstract readReview
In one paragraph

Review in The Journal of organic chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. JACS Au · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Enzymatic Kinetic Resolution by Addition of Oxygen.Angewandte Chemie (International ed. in English) · 2021
    Review
  9. Article
  10. Article
  11. Chemoenzymatic synthesis of spinosyn A.Angewandte Chemie (International ed. in English) · 2014
    Article
  12. Article
  13. Article
  14. Marine natural products: a new wave of drugs?Future medicinal chemistry · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonathan D MortisonLife Sciences Institute, Department of Chemistry and Department of Medicinal Chemistry, 210 Washtenaw Avenue, University of Michigan, Ann Arbor, Michigan 48109, USA.
David H Sherman

Funding

Molecular Analysis of Modular Polyketide SynthasesR01GM076477 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHERMAN, DAVID H, SMITH, JANET L. · 2006 to 2018
$5.2M
Biosynthetic Analysis of Marine Cyanobacterial PathwaysR01CA108874 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GERWICK, WILLIAM HENRY, SHERMAN, DAVID H · 2006 to 2015
$3.4M
NCI NIH HHS R01 CA108874NIGMS NIH HHS R01 GM076477
6 · The paper itself

Abstract

Natural product biosynthetic pathways have evolved enzymes with myriad activities that represent an expansive array of chemical transformations for constructing secondary metabolites. Recently, harnessing the biosynthetic potential of these enzymes through chemoenzymatic synthesis has provided a powerful tool that often rivals the most sophisticated methodologies in modern synthetic chemistry and provides new opportunities for accessing chemical diversity. Herein, we describe our research efforts with enzymes from a broad collection of biosynthetic systems, highlighting recent progress in this exciting field.

Indexed as

CyclizationEnzymesEpoxy CompoundsHumansHydroxylationPeptide SynthasesPolyketide SynthasesEnzymesEpoxy CompoundsPeptide SynthasesPolyketide Synthases

Identifiers

PMID20882949
PMCPMC2966535

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.