ReviewWiley interdisciplinary reviews. Systems biology and medicine
The zebrafish: scalable in vivo modeling for systems biology.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- A Focal Impact Model of Traumatic Brain Injury inInternational journal of molecular sciences · 2022Article
- Theabrownin triggers DNA damage to suppress human osteosarcoma U2OS cells by activating p53 signalling pathway.Journal of cellular and molecular medicine · 2018Article
- In vivo tissue has non-linear rheological behavior distinct from 3D biomimetic hydrogels, as determined by AMOTIV microscopy.Biomaterials · 2016Article
- Genome-wide association studies and contribution to cardiovascular physiology.Physiological genomics · 2015Review
- Zebrafish Models of Kidney Damage and Repair.Current pathobiology reports · 2015Article
- Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.Circulation · 2015Article
- Advances in genomics of bony fish.Briefings in functional genomics · 2014Review
- Integrative genomics in cardiovascular medicine.Cardiovascular research · 2013Review
- Zebrafish models for ectopic mineralization disorders: practical issues from morpholino design to post-injection observations.Frontiers in genetics · 2013Article
- Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish.Drug discovery today. Disease models · 2013Article
- Optical mapping in the developing zebrafish heart.Pediatric cardiology · 2012Review
- Next-generation genome-wide association studies: time to focus on phenotype?Circulation. Cardiovascular genetics · 2011Article
- Exploiting Analysis of Heterogeneity to Increase the Information Content Extracted from Fluorescence Micrographs of Transgenic Zebrafish Embryos.Assay and drug development technologiesArticle
- Pluripotent stem cell-derived hepatocyte-like cells.Biotechnology advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The zebrafish offers a scalable vertebrate model for many areas of biologic investigation. There is substantial conservation of genetic and genomic features and, at a higher order, conservation of intermolecular networks, as well as physiologic systems and phenotypes. We highlight recent work demonstrating the extent of this homology, and efforts to develop high-throughput phenotyping strategies suited to genetic or chemical screening on a scale compatible with in vivo validation for systems biology. We discuss the implications of these approaches for functional annotation of the genome, elucidation of multicellular processes in vivo, and mechanistic exploration of hypotheses generated by a broad range of 'unbiased' 'omic technologies such as expression profiling and genome-wide association. Finally, we outline potential strategies for the application of the zebrafish to the systematic study of phenotypic architecture, disease heterogeneity and drug responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.