ArticleDiabetes/metabolism research and reviews2010
Insulin resistance is related to impaired lung function in morbidly obese women: a case-control study.
Article in Diabetes/metabolism research and reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02889510 (Multicentre Randomized Double Blind, Crossover, Placebo Controlled Clinical Trial to Evaluate the Effect of Liraglutide on Lung Function in Patients With Type 2 Diabetes Mellitus), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicentre Randomized Double Blind, Crossover, Placebo Controlled Clinical Trial to Evaluate the Effect of Liraglutide on Lung Function in Patients With Type 2 Diabetes Mellitus (LIRALUNG Study)
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
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- Genetic Correlation and Bidirectional Causal Association Between Type 2 Diabetes and Pulmonary Function.Frontiers in endocrinology · 2021Article
- Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome.BMC endocrine disorders · 2020Article
- Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study.Journal of clinical medicine · 2020Article
- Association between glycemic state and pulmonary function and effect of walking as a protective factor in subjects with diabetes mellitus.Annals of translational medicine · 2019Article
- Is obesity related to the lung function of non-asthmatic children?World journal of clinical pediatrics · 2018Review
- Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.Respiratory medicine · 2017Article
- The relation between insulin resistance and lung function: a cross sectional study.BMC pulmonary medicine · 2015Article
- Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma.The Journal of allergy and clinical immunology · 2015Article
- Characterization of sleep breathing pattern in patients with type 2 diabetes: sweet sleep study.PloS one · 2015Article
- Association of pulmonary function with adiposity and metabolic abnormalities in urban minority adolescents.Annals of the American Thoracic Society · 2014Article
- The modified Medical Research Council scale for the assessment of dyspnea in daily living in obesity: a pilot study.BMC pulmonary medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing evidence suggesting an association between type 2 diabetes and impaired pulmonary function. However, the role of insulin resistance itself remains to be elucidated. The aim of the study is to determine whether obese patients with insulin resistance without diabetes have reduced pulmonary function in comparison with non-diabetic obese subjects without insulin resistance.
methodsSeventy-five morbidly obese non-diabetic women [50 with an insulin resistance index (homeostasis model assessment, HOMA-IR) ≥ 3.8-cases-and 25 with HOMA-IR < 3.8-controls-] with a history of not smoking and without prior cardiovascular or respiratory disease were prospectively recruited in the outpatient Obesity Unit of a university hospital. Both groups were closely matched by age, body mass index and waist circumference. Pulmonary function test included a forced spirometry and static pulmonary volume measurements.
resultsPatients with HOMA-IR ≥ 3.8 showed lower forced expiratory volume at 1 s [mean difference - 7.6% of predicted (95% confidence interval - 14.2 to - 0.9); p = 0.025], and also a lower maximum midexpiratory flow [mean difference - 16.4% of predicted (95% confidence interval - 30.9 to - 2.0); p = 0.026] in comparison with those with HOMA-IR < 3.8. Significant negative correlations between HOMA-IR and forced expiratory volume at 1 s, maximum midexpiratory flow and forced vital capacity were detected. Multiple linear regression analysis showed that HOMA-IR (β = - 0.323, p = 0.002) and total lung capacity (β = 0.468, p < 0.001) were independently associated with forced expiratory volume at 1 s (r(2) = 0.358).
conclusionsInsulin resistance is related to respiratory function impairment in morbidly obese women. Our results strongly suggest that the metabolic pathways related to insulin resistance are crucial in initiating lung abnormalities previously described in type 2 diabetic patients. Copyright © 2010 John Wiley & Sons, Ltd.
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