ArticleMolecular and cellular biochemistry2011
Cloning, sequence identification, and tissue expression analysis of novel chicken NYGGF4 gene.
Article in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed, 6 citations in OpenAlex.
- Sulforaphane protects the heart from doxorubicin-induced toxicity.Free radical biology & medicine · 2015Article
- The identification of loci for immune traits in chickens using a genome-wide association study.PloS one · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
NYGGF4 is a recently discovered gene that is involved in obesity-associated insulin resistance. In this study, an Hi-Line Brown chicken homolog of the NYGGF4 gene was cloned, sequenced, and characterized. The NYGGF4 full-length coding sequence (CDS) consists of 654 bp and encodes 217 amino acids with a molecular mass of 25,00 kD. The phosphotyrosine binding (PTB) domain of NYGGF4 is well conserved between chicken and other animals. The three-dimensional structure of the NYGGF4 (57-192 AA) by homology modeling was similar to that of human FE65-PTB1 domain. The phylogenetic tree analysis revealed that the chicken NYGGF4 has closer genetic relationships and evolution distance with the land mammals NYGGF4. Several predicted microRNA target sites were found in the coding sequence of chicken NYGGF4 mRNA. Analysis by RT-PCR showed that the NYGGF4 transcript is constitutively expressed in the 11 tissues tested: liver, subcutaneous fat, kidney, muscle stomach, heart, skin, brain, small intestine, spleen, lung, and skeletal muscle. These data serve as a foundation for further insight into the chicken NYGGF4 gene.
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