ArticleThe Pediatric infectious disease journal2011
Changes in childhood diarrhea incidence in nicaragua following 3 years of universal infant rotavirus immunization.
Article in The Pediatric infectious disease journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination.PloS one · 2014Trial
- Seasonal Variations in Household Water Use, Microbiological Water Quality, and Challenges to the Provision of Adequate Drinking Water: A Case of Peri-urban and Informal Settlements of Hosanna Town, Southern Ethiopia.Environmental health insights · 2024Article
- Access to Drinking Water, Sanitation, and Hand Hygiene Facilities in the Peri-Urban and Informal Settlements of Hosanna Town, Southern Ethiopia.Environmental health insights · 2023Article
- Epidemiologic Features of Acute Pediatric Diarrhea in Managua, Nicaragua, from 2011 to 2019.The American journal of tropical medicine and hygiene · 2022Article
- Overview of the Development, Impacts, and Challenges of Live-Attenuated Oral Rotavirus Vaccines.Vaccines · 2020Review
- Diagnosing and tracing the pathogens of infantile infectious diarrhea by amplicon sequencing.Gut pathogens · 2019Article
- Risk Factors for Norovirus Gastroenteritis among Nicaraguan Children.The American journal of tropical medicine and hygiene · 2017Article
- Integrated community case management (iCCM) of childhood infection saves lives in hard-to-reach communities in Nicaragua.Revista panamericana de salud publica = Pan American journal of public health · 2017Observational
- Issues in pediatric vaccine-preventable diseases in low- to middle-income countries.Human vaccines & immunotherapeutics · 2016Review
- Diarrhea Prevalence, Care, and Risk Factors Among Poor Children Under 5 Years of Age in Mesoamerica.The American journal of tropical medicine and hygiene · 2016Article
- Article
- Etiology of childhood diarrhea after rotavirus vaccine introduction: a prospective, population-based study in Nicaragua.The Pediatric infectious disease journal · 2014Article
- Predominance of norovirus and sapovirus in Nicaragua after implementation of universal rotavirus vaccination.PloS one · 2014Article
- Rotavirus prevalence in the primary care setting in Nicaragua after universal infant rotavirus immunization.The American journal of tropical medicine and hygiene · 2011Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlthough the pentavalent rotavirus vaccine was highly efficacious against rotavirus diarrhea in clinical trials, the effectiveness of vaccine under field conditions in the developing world is unclear. In October 2006, Nicaragua became the first developing nation to implement universal infant immunization with the pentavalent rotavirus vaccine. To assess the effect of the immunization program, we examined the incidence of diarrhea episodes between 2003 and 2009 among children in the state of León, Nicaragua.
methodsWe extracted data on diarrhea episodes from health ministry records. We used scaled Poisson regression models to estimate diarrhea incidence rate ratios for the period following the program's implementation to the period before implementation.
resultsFollowing implementation of the immunization program, diarrhea episodes among infants were reduced (incidence rate ratios: 0.85, 95% confidence interval: 0.71-1.02) during the rotavirus season, but appear to have increased during other months.
conclusionsAlthough the immunization program appears effective in reducing diarrhea episodes during the rotavirus season, a large burden of diarrhea still persists during the remainder of the year.
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Registered trials
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