Trial reportAIDS (London, England)2010
The Regai Dzive Shiri project: results of a randomized trial of an HIV prevention intervention for youth.
Trial report in AIDS (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 19 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 19 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Parent-adolescent sexual and reproductive health information communication in Ghana.Reproductive health · 2025Pooled it
- Use of contraceptives, empowerment and agency of adolescent girls and young women: a systematic review and meta-analysis.BMJ sexual & reproductive health · 2024Pooled it
- Pooled it
- Community level youth-led interventions to improve maternal-neonatal outcomes in low- and middle-income countries: A systematic review of randomised trials.Journal of global health · 2023Pooled it
- Quantitative Methods Used to Evaluate Impact of Combination HIV Prevention Intervention: A Methodological Systematic Review.AIDS and behavior · 2023Pooled it
- Some Interventions to Shift Meta-Norms Are Effective for Changing Behaviors in Low- and Middle-Income Countries: A Rapid Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Implementation Strategies to Enhance Youth-Friendly Sexual and Reproductive Health Services in Sub-Saharan Africa: A Systematic Review.Frontiers in reproductive health · 2021Pooled it
- Gender-transformative programming with men and boys to improve sexual and reproductive health and rights: a systematic review of intervention studies.BMJ global health · 2020Pooled it
- A systematic review of sexual and reproductive health interventions for young people in humanitarian and lower-and-middle-income country settings.BMC public health · 2020Pooled it
- Pooled it
- Peer-facilitated community-based interventions for adolescent health in low- and middle-income countries: A systematic review.PloS one · 2019Pooled it
- Theory-based interventions for contraception.The Cochrane database of systematic reviews · 2016Pooled it
- School-based interventions for preventing HIV, sexually transmitted infections, and pregnancy in adolescents.The Cochrane database of systematic reviews · 2016Pooled it
- School-based sexual health education interventions to prevent STI/HIV in sub-Saharan Africa: a systematic review and meta-analysis.BMC public health · 2016Pooled it
- School-based interventions for improving contraceptive use in adolescents.The Cochrane database of systematic reviews · 2016Pooled it
- The impact of community mobilisation on HIV prevention in middle and low income countries: a systematic review and critique.AIDS and behavior · 2014Pooled it
- Structural and community-level interventions for increasing condom use to prevent the transmission of HIV and other sexually transmitted infections.The Cochrane database of systematic reviews · 2014Pooled it
- Behavioral interventions for improving condom use for dual protection.The Cochrane database of systematic reviews · 2013Pooled it
- What works where? A systematic review of child and adolescent mental health interventions for low and middle income countries.Social psychiatry and psychiatric epidemiology · 2013Pooled it
- Trial
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundHIV prevention among young people in southern Africa is a public health priority. There is little rigorous evidence of the effectiveness of different intervention approaches. We describe findings of a cluster randomized trial of a community-based, multicomponent HIV, and reproductive health intervention aimed at changing social norms for adolescents in rural Zimbabwe.
methodsThirty rural communities were randomized to early or deferred implementation of the intervention in 2003. Impact was assessed in a representative survey of 18-22-year-olds after 4 years. Participants self-completed a questionnaire and gave a dried blood spot sample for HIV and herpes simplex virus-2 (HSV-2) antibody testing. Young women had a urinary pregnancy test. Analyses were by intention-to-treat and were adjusted for clustering.
findingsFour thousand six hundred and eighty-four, 18-22-year-olds participated in the survey (97.1% of eligible candidates, 55.5% women). Just over 40% had been exposed to at least 10 intervention sessions. There were modest improvements in knowledge and attitudes among young men and women in intervention communities, but no impact on self-reported sexual behavior. There was no impact of the intervention on prevalence of HIV or HSV-2 or current pregnancy. Women in intervention communities were less likely to report ever having been pregnant.
interpretationDespite an impact on knowledge, some attitudes, and reported pregnancy, there was no impact of this intervention on HIV or HSV-2 prevalence, further evidence that behavioral interventions alone are unlikely to be sufficient to reverse the HIV epidemic. The challenge remains to find effective HIV prevention approaches for young people in the face of continued and unacceptably high HIV incidence, particularly among young women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.