ArticleInvestigative ophthalmology & visual science2011
Reduced choroidal neovascular membrane formation in cyclooxygenase-2 null mice.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Analysis of 24 pro-inflammatory cytokines in aqueous and serum of 94 patients without diabetes.The British journal of ophthalmology · 2025Trial
- Analysis of Aqueous Interleukin-6 in Diabetic Retinopathy: A Prospective, Controlled Trial of 328 Eyes.Ophthalmology. Retina · 2026Article
- Classification of Diabetic Retinopathy Severity with Aqueous VEGF Levels: A Prospective, Observational Study.Ophthalmology science · 2026Article
- Intracellular Signaling Pathways and Their Potential Targeting for Treatment of Ocular Posterior Segment Fibrosis.Journal of ophthalmic & vision research · 2025Review
- Attenuation of Laser-Induced Choroidal Neovascularization by Blockade of Prostaglandin D2 Receptor 2.Translational vision science & technology · 2023Article
- Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.Molecular vision · 2019Article
- Targeted Imaging of VCAM-1 mRNA in a Mouse Model of Laser-Induced Choroidal Neovascularization Using Antisense Hairpin-DNA-Functionalized Gold-Nanoparticles.Molecular pharmaceutics · 2018Article
- Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization.International ophthalmology · 2018Article
- The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis.PloS one · 2016Article
- Protective effects of resveratrol against UVA-induced damage in ARPE19 cells.International journal of molecular sciences · 2015Article
- Novel Approaches for Retinal Drug and Gene Delivery.Translational vision science & technology · 2014Article
- The safety, pharmacokinetics, and efficacy of intraocular celecoxib.Investigative ophthalmology & visual science · 2014Article
- Nonsteroidal anti-inflammatory drugs for retinal disease.International journal of inflammation · 2013Article
- Effects of intravitreal bevacizumab (Avastin) on the porcine retina.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011Article
- Critical appraisal of ophthalmic ketorolac in treatment of pain and inflammation following cataract surgery.Clinical ophthalmology (Auckland, N.Z.) · 2011Article
- Cysteine-rich 61 mediates inflammation by the NF-κB/cyclooxygenase-2 pathway in RF/6A cells.Taiwan journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo assess the degree of laser-induced choroidal neovascular membrane formation in wild-type (WT) and COX-2 null mice and to measure vascular endothelial growth factor (VEGF), interleukin (IL)-1β, and tumor necrosis factor (TNF)-α levels in the retina and choroid.
methodsFour laser burns were placed in each eye of WT and COX-2 null mice to induce choroidal neovascularization. Fluorescein angiography (FA) was performed at 14 days, and retinal pigment epithelium-choroid-sclera (choroidal) flat mounts were prepared. The retina and choroid were isolated from WT and COX-2 null mice at 24, 72, and 168 hours after laser photocoagulation and from unlasered eyes and were tested for VEGF, IL-1β, and TNF-α.
resultsCOX-2 null mice demonstrated 58% (P = 0.001) and 48% (P = 0.001) reductions in CNV formation on FA and choroidal flat mounts, respectively, compared with WT mice. For unlasered mice, mean VEGF concentrations in the retina and choroid were 1.2 ± 0.42 pg/mg protein for WT but only 0.42 ± 0.2 pg/mg protein for COX-2 null mice (P < 0.05). After laser photocoagulation, WT mice showed significantly greater VEGF and IL-β expression in the retina and choroid by 168 hours (P < 0.05) and 72 hours (P < 0.05), respectively, compared with COX-2 null mice.
conclusionsCOX-2 null mice exhibited significantly less choroidal neovascular membrane formation associated with reduced expression of VEGF. The results of this study suggest that COX-2 modulates VEGF expression in CNV and implicates a potential therapeutic role for nonsteroidal anti-inflammatory drugs.
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