ReviewThe Journal of clinical endocrinology and metabolism2011
Clinical review: Why is androgen replacement in males controversial?
Review in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2015Guideline
- A Randomized Double-Blind Placebo-Controlled Trial of a Botanical Formulation for Symptom Management in Male Climacteric Syndrome.Medicina (Kaunas, Lithuania) · 2026Trial
- Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels.The Journal of clinical endocrinology and metabolism · 2016Trial
- Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japan (EARTH Study).Asian journal of andrologyTrial
- Ultra-processed foods intake and sex hormone levels among children and adolescents aged 6-19 years: a cross-sectional study.Frontiers in nutrition · 2024Article
- From mitochondria to sarcopenia: role of 17β-estradiol and testosterone.Frontiers in endocrinology · 2023Review
- Midlife Chronological and Endocrinological Transitions in Brain Metabolism: System Biology Basis for Increased Alzheimer's Risk in Female Brain.Scientific reports · 2020Article
- Hypogonadism, Type-2 Diabetes Mellitus, and Bone Health: A Narrative Review.Frontiers in endocrinology · 2020Review
- Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats.Frontiers in aging neuroscience · 2017Article
- Serum Testosterone Concentrations and Urinary Bisphenol A, Benzophenone-3, Triclosan, and Paraben Levels in Male and Female Children and Adolescents: NHANES 2011-2012.Environmental health perspectives · 2016Article
- Issues Surrounding Testosterone Replacement Therapy.Hospital pharmacy · 2016Article
- Testosterone replacement attenuates cognitive decline in testosterone-deprived lean rats, but not in obese rats, by mitigating brain oxidative stress.Age (Dordrecht, Netherlands) · 2015Article
- Testosterone deficiency, insulin-resistant obesity and cognitive function.Metabolic brain disease · 2015Review
- Andropause - state of the art 2015 and review of selected aspects.Przeglad menopauzalny = Menopause review · 2015Article
- A review of the relationships between endogenous sex steroids and incident ischemic stroke and coronary heart disease events.Current cardiology reviews · 2015Review
- Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model.Cell and tissue research · 2014Article
- Gynecomastia in subjects with sexual dysfunction.Journal of endocrinological investigation · 2014Article
- Protective effects of testosterone on presynaptic terminals against oligomeric β-amyloid peptide in primary culture of hippocampal neurons.BioMed research international · 2014Article
- Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2014Article
- Andropause: Current concepts.Indian journal of endocrinology and metabolism · 2013Review
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextSymptoms and signs consistent with androgen deficiency and low testosterone levels are recognized frequently in clinical practice. Recent population-based epidemiological studies indicate that low testosterone levels in men are associated with increased morbidity and mortality. The clinician must be able to counsel patients to help them determine whether testosterone replacement therapy is appropriate for them. EVIDENCE ACQUISITION: The authors have conducted a literature search in PubMed, and we have reviewed references in the multiple systematic reviews and meta-analyses that have been published on this topic. EVIDENCE SYNTHESIS: We have attempted to provide the reader with an appreciation of the evidence that can be used to support the diagnosis of androgen deficiency, the efficacy of treatment, the potential risks of treatment, the therapeutic options, and the recommendations for monitoring treatment.
conclusionsWe think that published clinical experience justifies testosterone replacement therapy in males who have not initiated puberty by age 14 and in males with low testosterone levels due to classical diseases of the hypothalamic-pituitary-gonadal axis. The benefit:risk ratio is less certain in older men and in those with chronic diseases associated with low testosterone levels. The decision to treat in this setting is much more controversial because there are few large clinical trials that have demonstrated efficacy and no large clinical trials that have determined potential risks of increasing the incidence of clinical prostate cancers or cardiovascular events. We provide a critical review of the evidence that supports treatment and potential risks and ways to reduce the risks if the physician and patient elect testosterone replacement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.