ArticleThe Journal of clinical endocrinology and metabolism2010
Indian Hedgehog and its targets in human endometrium: menstrual cycle expression and response to CDB-2914.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Disruption of primary ciliary prostaglandin EJournal of biomedical science · 2026Article
- Review
- Transcriptomics Reveals the Differences in mRNA Expression Patterns in Yak Uterus of Follicular, Luteal, and Pregnant Phases.Animals : an open access journal from MDPI · 2025Article
- Hedgehog signaling is required for endometrial remodeling and myometrial homeostasis in the cycling mouse uterus.iScience · 2023Article
- Establishment of the fetal-maternal interface: developmental events in human implantation and placentation.Frontiers in cell and developmental biology · 2023Review
- BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis.Human reproduction update · 2022Review
- Deciphering the endometrial niche of human thin endometrium at single-cell resolution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Illuminating the "Black Box" of Progesterone-Dependent Embryo Implantation Using Engineered Mice.Frontiers in cell and developmental biology · 2021Review
- Sonic Hedgehog as a Regulator of Endometrial Mesenchymal Stem/Stromal Cell Activity.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Molecular Studies on Pregnancy with Mouse Models.Current opinion in physiology · 2020Article
- Self-renewing endometrial epithelial organoids of the human uterus.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis.Annals of translational medicine · 2019Article
- Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation.Reproductive medicine and biology · 2019Review
- Uterine fibroids: an update on current and emerging medical treatment options.Therapeutics and clinical risk management · 2019Review
- KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance.Scientific reports · 2017Article
- The regulation of Hh/Gli1 signaling cascade involves Gsk3β- mediated mechanism in estrogen-derived endometrial hyperplasia.Scientific reports · 2017Article
- Selective progesterone receptor modulator (SPRM) ulipristal acetate (UPA) and its effects on the human endometrium.Human reproduction (Oxford, England) · 2017Article
- miR-200 Regulates Endometrial Development During Early Pregnancy.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis.Biology of reproduction · 2016Article
- Minireview: Steroid-regulated paracrine mechanisms controlling implantation.Molecular endocrinology (Baltimore, Md.) · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
contextProgesterone is critical for secretory endometrial differentiation in women, but its downstream mediators are poorly understood.
objectiveOur objective was to investigate endometrial expression of Indian Hedgehog (IHH) and genes involved in its signaling [smoothened (SMO), patched-1 (PTCH1), glioma-associated oncogene homolog 1 (GLI1), and GLI2] during the menstrual cycle and the effects of the selective progesterone receptor modulator CDB-2914 on its expression. DESIGN AND
settingComparisons between normally cycling volunteers and women with symptomatic fibroids who received CDB-2914 or placebo were made at a clinical research center. PATIENTS AND
interventionsEndometrial biopsy was performed on 34 volunteers, 17 additional women with fibroids.
main outcome measuresEndometrial expression of IHH, SMO, PTCH1, GLI1, and GLI2 by in situ hybridization and/or RT-PCR and IHH, GLI1, and PTCH1 immunohistochemistry were evaluated.
resultsRT-PCR showed expression of IHH, SMO, PTCH1, GLI1, and GLI2, with significant increases in IHH (5.2-fold) and GLI1 (3.6-fold) in endometrium exposed to CDB-2914 compared with placebo. In situ hybridization showed IHH mRNA expression in glands and stroma that was stronger in secretory samples. Among volunteers, IHH and GLI1 immunohistochemistry scores were higher in the secretory than proliferative phase in the nuclei and cytoplasm of glands and stroma (P=0.0002-0.04). Compared with follicular-phase controls, women exposed to CDB-2914 showed increased IHH expression in all compartments except stromal cytoplasm (P=0.0199-0.0423); GLI1 was up-regulated in glandular nuclei and cytoplasm compared with both volunteers and women receiving placebo (P≤0.0416).
conclusionsThe temporal increase in endometrial IHH and GLI1 during the secretory phase, and their modulation by CDB-2914, suggests progestin regulation and a potential role in endometrial differentiation and implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.