ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- FcγR- and CD9-dependent synapse-engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage in mice.Nature communications · 2026Article
- The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents.Frontiers in neural circuits · 2025Review
- CD3ζ-Mediated Signaling Protects Retinal Ganglion Cells in Glutamate Excitotoxicity of the Retina.Cells · 2024Article
- Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.Nature communications · 2022Article
- Involvement of Denervated Midbrain-Derived Factors in the Formation of Ectopic Cortico-Mesencephalic Projection after Hemispherectomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Lesion Area in the Cerebral Cortex Determines the Patterns of Axon Rewiring of Motor and Sensory Corticospinal Tracts After Stroke.Frontiers in neuroscience · 2021Article
- Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury.Cell death & disease · 2020Article
- Establishment of axon regeneration regulatory network and the role of low intensity pulsed ultrasound in the network.Saudi journal of biological sciences · 2019Article
- Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice.BMC genomics · 2019Article
- Nucleic Acid Vaccine Targeting Nogo-66 Receptor and Paired Immunoglobulin-Like Receptor B as an Immunotherapy Strategy for Spinal Cord Injury in Rats.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors.EBioMedicine · 2018Article
- The Involvement of the Myelin-Associated Inhibitors and Their Receptors in CNS Plasticity and Injury.Molecular neurobiology · 2018Review
- PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury.Cellular and molecular neurobiology · 2017Article
- Mechanisms of Axonal Damage and Repair after Central Nervous System Injury.Translational stroke research · 2017Review
- The effects of immune protein CD3ζ development and degeneration of retinal neurons after optic nerve injury.PloS one · 2017Article
- Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior.Frontiers in aging neuroscience · 2017Article
- Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Ameliorative Effects of p75NTR-ED-Fc on Axonal Regeneration and Functional Recovery in Spinal Cord-Injured Rats.Molecular neurobiology · 2015Article
- The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system.Neural regeneration research · 2015Review
- Axon regeneration impediment: the role of paired immunoglobulin-like receptor B.Neural regeneration research · 2015Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rewiring of neural networks is a fundamental step in recovering behavioral functions after brain injury. However, there is limited potential for axonal plasticity in the adult CNS. The myelin-associated proteins Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMgp) are known to inhibit axonal plasticity, and thus targeting the inhibitory pathways they participate in is a potential means of promoting plasticity and functional recovery. Each of Nogo, MAG, and OMgp interacts with both the Nogo receptor (NgR) and paired immunoglobulin-like receptor B (PirB). Here, we determined whether blocking PirB activity enhances axonal reorganization and functional recovery after cortical injury. We found that axons of the contralesional corticospinal tract sprouted into the denervated side of the cervical spinal cord after unilateral injury of the motor cortex. The extent to which this axonal reorganization occurred was far greater in mice lesioned during early postnatal days than in mice lesioned at an age when myelin had begun to form. This suggests that myelin-associated proteins might limit axonal remodeling in vivo. However, the number of sprouting fibers within either the corticospinal or corticorubral tract was not enhanced in PirB(-/-) mice. Blocking PirB signaling also failed to enhance functional recovery with three motor tests. Our results suggest that blocking the function of PirB is not sufficient to promote axonal reorganization or functional recovery after cortical injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.