ArticleThe Journal of pharmacology and experimental therapeutics2011
Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.
Article in The Journal of pharmacology and experimental therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 97 citations in OpenAlex.
- The Effect of Pyrethroid Ingestion on Butyrylcholinesterase Level.European journal of case reports in internal medicine · 2026Article
- Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, andFrontiers in pharmacology · 2024Article
- Article
- Effects of prenatal pesticide exposure on the fetal brain and placenta transcriptomes in a rodent model.Toxicology · 2023Article
- Agricultural surface water, imidacloprid, and chlorantraniliprole result in altered gene expression and receptor activation in Pimephales promelas.The Science of the total environment · 2022Article
- Cypermethrin induces Sertoli cell apoptosis through mitochondrial pathway associated with calcium.Toxicology research · 2021Article
- Dengue fever and insecticide resistance in Aedes mosquitoes in Southeast Asia: a review.Parasites & vectors · 2021Review
- Human neuronal signaling and communication assays to assess functional neurotoxicity.Archives of toxicology · 2021Article
- Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte,Journal of natural products · 2020Article
- Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system.Cell death discovery · 2020Article
- Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors.Environmental health perspectives · 2019Article
- Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Modification of distinct ion channels differentially modulates CaScientific reports · 2017Article
- Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.Nature communications · 2016Article
- Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows.PloS one · 2015Article
- Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons.The Journal of pharmacology and experimental therapeutics · 2014Article
- Inhibition of voltage-gated calcium channels as common mode of action for (mixtures of) distinct classes of insecticides.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity.Molecular pharmacology · 2014Article
- New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis.Journal of applied toxicology : JAT · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Pyrethroid insecticides bind to voltage-gated sodium channels (VGSCs) and modify their gating kinetics, thereby disrupting neuronal function. Pyrethroids have also been reported to alter the function of other channel types, including activation of voltage-gated calcium channels. Therefore, the present study compared the ability of 11 structurally diverse pyrethroids to evoke Ca(2+) influx in primary cultures of mouse neocortical neurons. Nine pyrethroids (tefluthrin, deltamethrin, λ-cyhalothrin, β-cyfluthrin, esfenvalerate, S-bioallethrin, fenpropathrin, cypermethrin, and bifenthrin) produced concentration-dependent elevations in intracellular calcium concentration ([Ca(2+)](i)) in neocortical neurons. Permethrin and resmethrin were without effect on [Ca(2+)](i). These pyrethroids displayed a range of efficacies on Ca(2+) influx; however, the EC(50) values for active pyrethroids all were within one order of magnitude. Tetrodotoxin blocked increases in [Ca(2+)](i) caused by all nine active pyrethroids, indicating that the effects depended on VGSC activation. The pathways for deltamethrin- and tefluthrin-induced Ca(2+) influx include N-methyl-D-aspartic acid receptors, L-type Ca(2+) channels, and reverse mode of operation of the Na(+)/Ca(2+) exchanger inasmuch as antagonists of these sites blocked deltamethrin-induced Ca(2+) influx. These data demonstrate that pyrethroids stimulate Ca(2+) entry into neurons subsequent to their actions on VGSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.