ArticleThe Journal of biological chemistry2010
The TFIIB tip domain couples transcription initiation to events involved in RNA processing.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Interplay of mRNA capping and transcription machineries.Bioscience reports · 2020Review
- Linking Core Promoter Classes to Circadian Transcription.PLoS genetics · 2016Article
- Transcription initiation factor IIB involves in Schwann cell differentiation after rat sciatic nerve crush.Journal of molecular neuroscience : MN · 2013Article
- Transcription factor TFIIF is not required for initiation by RNA polymerase II, but it is essential to stabilize transcription factor TFIIB in early elongation complexes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
TFIIB is the only factor within the multimegadalton transcription complex that is obligatorily required to undergo dissociation and re-association with each round of mRNA transcription. Here we show that a six-amino acid human TFIIB tip region is needed for appropriate levels of serine 5 C-terminal domain phosphorylation and mRNA capping and for retention of the required elongation factor TFIIF. We suggest that the broad functions of this tiny region are used to suppress transcription noise by restricting functional RNA synthesis from non-promoter sites on the genome, which will not contain TFIIB.
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Registered trials
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