ReviewEnvironmental health perspectives2011
Occupational benzene exposure and the risk of lymphoma subtypes: a meta-analysis of cohort studies incorporating three study quality dimensions.
Review in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 9 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2024Pooled it
- Metal Exposure and Risk of Parkinson Disease: A Systematic Review and Meta-Analysis.American journal of epidemiology · 2023Pooled it
- Benzene exposure and non-Hodgkin lymphoma: a systematic review and meta-analysis of human studies.The Lancet. Planetary health · 2021Pooled it
- Challenges and recommendations on the conduct of systematic reviews of observational epidemiologic studies in environmental and occupational health.Journal of exposure science & environmental epidemiology · 2021Pooled it
- Pooled study of occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma.Occupational and environmental medicine · 2018Pooled it
- Parental, In Utero, and Early-Life Exposure to Benzene and the Risk of Childhood Leukemia: A Meta-Analysis.American journal of epidemiology · 2016Pooled it
- Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results.Environmental health perspectives · 2012Pooled it
- A meta-analysis of asbestos and lung cancer: is better quality exposure assessment associated with steeper slopes of the exposure-response relationships?Environmental health perspectives · 2011Pooled it
- Trichloroethylene and cancer: systematic and quantitative review of epidemiologic evidence for identifying hazards.International journal of environmental research and public health · 2011Pooled it
- Association Between Job Characteristics, Benzene Exposure, and Hematopoietic Cancer Risk in Subway Maintenance Workers.Safety and health at work · 2026Article
- Chronic lymphatic leukaemia in a worker with a long-term occupational exposure to petroleum product mixtures: a case report.Arhiv za higijenu rada i toksikologiju · 2026Article
- Occupational Benzene Exposure and Hepatobiliary and Pancreatic Cancers: A Systematic Review and Meta-analysis.Safety and health at work · 2026Review
- Environmental and occupational risk factors associated with multiple myeloma: a multicenter, hospital-based, matched case-control study.BMC public health · 2025Article
- Occupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men's Health Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Cancer Incidence among Marines and Navy Personnel and Civilian Workers Exposed to Industrial Solvents in Drinking Water at US Marine Corps Base Camp Lejeune: A Cohort Study.Environmental health perspectives · 2024Article
- Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments.EFSA journal. European Food Safety Authority · 2024Article
- Occupational exposure to benzene and mortality risk of lymphohaematopoietic cancers in the Swiss National Cohort.Scandinavian journal of work, environment & health · 2024Article
- Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies.American journal of respiratory and critical care medicine · 2024Article
- Mitochondrial DNA Fragmentation and Risk of Non-Hodgkin Lymphoma.JAMA network open · 2023Article
- Environmental exposures and lymphoma risk: a nested case-control study using the Golden Retriever Lifetime Study cohort.Canine medicine and genetics · 2022Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe use of occupational cohort studies to assess the association of benzene and lymphoma is complicated by problems with exposure misclassification, outcome classification, and low statistical power.
objectiveWe performed meta-analyses of occupational cohort studies for five different lymphoma categories: Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), multiple myeloma (MM), acute lymphocytic leukemia (ALL), and chronic lymphocytic leukemia (CLL). DATA EXTRACTION: We assessed three study quality dimensions to evaluate the impact of study quality variations on meta-relative risks (mRRs): stratification by the year of start of follow-up, stratification by the strength of the reported acute myelogenous leukemia association, and stratification by the quality of benzene exposure assessment. DATA SYNTHESIS: mRRs for MM, ALL, and CLL increased with increasing study quality, regardless of the study quality dimension. mRRs for NHL also increased with increasing study quality, although this effect was less pronounced. We observed no association between occupational benzene exposure and HL.
conclusionsOur meta-analysis provides support for an association between occupational benzene exposure and risk of MM, ALL, and CLL. The evidence for an association with NHL is less clear, but this is likely complicated by the etiologic heterogeneity of this group of diseases. Further consideration of the association between benzene and NHL will require delineation of risks by NHL subtype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.