ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2011
The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review.BMC pediatrics · 2020Pooled it
- Long-term safety of prenatal and neonatal exposure to paracetamol: a protocol for a systematic review.BMJ paediatrics open · 2020Pooled it
- [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].Schmerz (Berlin, Germany) · 2014Guideline
- Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma.Contemporary clinical trials · 2021Trial
- Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.The New England journal of medicine · 2016Trial
- Increased fecal human beta-defensin-2 expression in preterm infants is associated with allergic disease development in early childhood.The World Allergy Organization journal · 2022Article
- Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues.Current environmental health reports · 2021Review
- Acetaminophen use and asthma in children.Canadian family physician Medecin de famille canadien · 2017Review
- Article
- Prenatal and infant paracetamol exposure and development of asthma: the Norwegian Mother and Child Cohort Study.International journal of epidemiology · 2016Article
- Clinical pharmacology of paracetamol in neonates: a review.Current therapeutic research, clinical and experimental · 2015Review
- Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.Thorax · 2015Article
- Causal assessment of pharmaceutical treatments: why standards of evidence should not be the same for benefits and harms?Drug safety · 2015Article
- The association between acetaminophen and asthma: is there anything to learn from the upper airways?Current opinion in allergy and clinical immunology · 2014Review
- Safety vs. efficacy assessment of pharmaceuticals: Epistemological rationales and methods.Preventive medicine reports · 2014Article
- The case of drug causation of childhood asthma: antibiotics and paracetamol.European journal of clinical pharmacology · 2013Review
- Balancing the risks and benefits of the use of over-the-counter pain medications in children.Drug safety · 2012Review
- Have the efforts to prevent aspirin-related Reye's syndrome fuelled an increase in asthma?Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2011Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite reports of positive associations between paracetamol and asthma, the nature of these associations is unclear.
objectiveWe aimed to investigate the associations between infant and childhood paracetamol use and atopy and allergic disease at 5-6 years.
methodsIn a birth cohort study, we collected reported paracetamol exposure between birth and 15 months in Christchurch (n=505) and between 5 and 6 years for all participants (Christchurch and Wellington) (n=914). Outcome data for reported current asthma, reported wheeze and atopy (measured using skin prick tests) were collected at 6 years for all participants. Logistic regression models were adjusted for potential confounders, including the number of chest infections and antibiotic use.
resultsParacetamol exposure before the age of 15 months was associated with atopy at 6 years [adjusted odds ratio (OR)=3.61, 95% confidence interval (CI) 1.33-9.77]. Paracetamol exposure between 5 and 6 years showed dose-dependent associations with reported wheeze and current asthma but there was no association with atopy. Compared with use 0-2 times, the adjusted OR (95% CI) were wheeze 1.83 (1.04-3.23) for use 3-10 times, and 2.30 (1.28-4.16) for use >10 times: current asthma 1.63 (0.92-2.89) for use 3-10 times and 2.16 (1.19-3.92) for use >10 times: atopy 0.96 (0.59-1.56) for use 3-10 times, and 1.05 (0.62-1.77) for use >10 times. CONCLUSION AND CLINICAL RELEVANCE: Our findings suggest that paracetamol has a role in the development of atopy, and the maintenance of asthma symptoms. Before recommendations for clinical practice can be made, randomized-controlled trials are needed to determine whether these associations are causal.
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