ArticleThe Journal of comparative neurology2010
Neuregulin-1 at synapses on phrenic motoneurons.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Size-dependent alterations in phrenic motor neuron perineuronal nets following cervical spinal hemisection.Journal of neurophysiology · 2026Article
- Article
- Cervical spinal hemisection alters phrenic motor neuron glutamatergic mRNA receptor expression.Experimental neurology · 2022Article
- Electrical Properties of Adult Mammalian Motoneurons.Advances in neurobiology · 2022Article
- Quantifying mitochondrial volume density in phrenic motor neurons.Journal of neuroscience methods · 2021Article
- Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1Frontiers in neurology · 2021Article
- Disproportionate loss of excitatory inputs to smaller phrenic motor neurons following cervical spinal hemisection.The Journal of physiology · 2020Article
- Heterogeneous glutamatergic receptor mRNA expression across phrenic motor neurons in rats.Journal of neurochemistry · 2020Article
- Phrenic motor neuron loss in an animal model of early onset hypertonia.Journal of neurophysiology · 2020Article
- Glutamatergic input varies with phrenic motor neuron size.Journal of neurophysiology · 2019Article
- Frequency-dependent lipid raft uptake at rat diaphragm muscle axon terminals.Muscle & nerve · 2019Article
- Phrenic motoneuron structural plasticity across models of diaphragm muscle paralysis.The Journal of comparative neurology · 2018Article
- Differences in lumbar motor neuron pruning in an animal model of early onset spasticity.Journal of neurophysiology · 2018Article
- Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Phrenic motor neuron loss in aged rats.Journal of neurophysiology · 2018Article
- Motoneuron glutamatergic receptor expression following recovery from cervical spinal hemisection.The Journal of comparative neurology · 2017Article
- Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury.Scientific reports · 2017Article
- Neuregulin 1 Reduces Motoneuron Cell Death and Promotes Neurite Growth in anFrontiers in cellular neuroscience · 2017Article
- The Impact of Midcervical Contusion Injury on Diaphragm Muscle Function.Journal of neurotrauma · 2016Article
- Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.Acta neuropathologica communications · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The neuregulin (NRG) family of trophic factors is present in the central and peripheral nervous systems and participates in the survival, proliferation, and differentiation of many different cell types, including motoneurons. NRG1 was first characterized by its role in the formation of the neuromuscular junction, and recently it was shown to play a crucial role in modulating glutamatergic and cholinergic transmission in the central nervous system of adult rats. However, little is known about NRG1's role in adult motor systems. Motoneurons receive dense glutamatergic and cholinergic input. We hypothesized that NRG1 is present at synapses on phrenic motoneurons. Confocal microscopy and 3D reconstruction techniques were used to determine the distribution of NRG1 and its colocalization with these different neurotransmitter systems. We found that NRG1 puncta are present around retrogradely labeled motoneurons and are distributed predominantly at motoneuron somata and primary dendrites. NRG1 is present exclusively at synaptic sites (identified using the presynaptic marker synaptophysin), making up ∼30% of all synapses at phrenic motoneurons. Overall, NRG1 immunoreactivity is found predominantly at cholinergic synapses (75% ± 14% colocalize with the vesicular acetylcholine transporter; VAChT). Nearly all (99% ± 1%) VAChT-immunoreactive synapses expressed NRG1. NRG1 also is present at a subset of glutamatergic synapses expressing the vesicular glutamate transporter (VGLUT) type 2 (∼6%) but not those expressing VGLUT type 1. Overall, 26% ± 6% of NRG1 synapses are VGLUT2 immunoreactive. These findings provide the first evidence suggesting that NRG1 may modulate synaptic activity in adult motor systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.