Evidence map›Paper›PMID 20878529›Full record

SynthesisJournal of cancer research and clinical oncology2011

Prognostic role of systemic inflammatory response in renal cell carcinoma: a systematic review and meta-analysis.

Ying Wu, Xiaonan Fu, Xiaoli Zhu, Xuelian He, Chao Zou, Yijie Han, Mingchu Xu, Chengjin Huang, Xin Lu, Yulan Zhao

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cancer research and clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 7 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 7 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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  2. A Meta-Analysis of C-Reactive Protein in Patients With Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ying WuAdvanced Institute of NBIC Integrated Drug Discovery and Development, East China Normal University, North Zhongshan Road #3663, Shanghai, 200062, People's Republic of China.
Xiaonan Fu
Xiaoli Zhu
Xuelian He
Chao Zou
Yijie Han
Mingchu Xu
Chengjin Huang
Xin Lu
Yulan Zhao
East China Normal University · CNPeking Union Medical College Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNWuhan Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo summarize the global predicting role of systemic inflammatory response for survival in renal cell carcinoma.

methodsEligible studies were identified and assessed for quality through multiple search strategies. Data were collected from studies comparing overall, cancer-specific or relapse-free survival in patients with elevated C-reactive protein (CRP), platelet count (PC) and erythrocyte sedimentation rate (ESR) levels with those with lower levels. Studies were pooled, and combined hazard ratios (HRs) of CRP, PC and ESR for survival were calculated, respectively.

resultsA total of 47 studies were included for meta-analysis (18 for CRP, 15 for PC and 14 for ESR). For overall survival, the pooled HR of CRP (3.23, 95% CI: 1.77, 5.89) was higher than that of PC (1.96, 95% CI: 1.40, 2.75) and that of ESR (1.86, 95% CI: 1.34, 2.59). These indicators were strong predictors for cancer-specific survival with individual HRs being 3.46 (95% CI, 2.80, 4.27) of CRP, 3.22 (95% CI, 2.25, 4.62) of PC, and 3.85 (95% CI, 3.31, 4.48) of ESR, respectively. All three inflammatory indictors also predicted relapse-free survival (HRs > 2.0).

conclusionThe systemic inflammatory response predicted poor survival in patients with renal cell carcinoma.

Indexed as

Blood SedimentationCarcinoma, Renal CellC-Reactive ProteinHumansInflammationKidney NeoplasmsPlatelet CountPrognosisC-Reactive Protein

Identifiers

PMID20878529
PMCPMC11828339
OpenAlexW2123096356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.