ReviewCurrent gastroenterology reports2010
The aging colon: the role of enteric neurodegeneration in constipation.
Review in Current gastroenterology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- Inflammatory and morphological changes in the colon reflect early aging induced by D-galactose in rats.Scientific reports · 2025Article
- The human colon: Evidence for degenerative changes during aging and the physiological consequences.Neurogastroenterology and motility · 2025Review
- Regulatory and Influencing Factors of Digestive Function in Elderly People: Roles of the Gut Microbiota and Nutritional Interventions.Aging and disease · 2025Review
- Aging-related impairment of neurogenic chloride secretion in human colon mucosa.Frontiers in physiology · 2025Article
- Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy.Redox report : communications in free radical research · 2024Review
- Aberrant bowel movement frequencies coincide with increased microbe-derived blood metabolites associated with reduced organ function.Cell reports. Medicine · 2024Article
- Generally-healthy individuals with aberrant bowel movement frequencies show enrichment for microbially-derived blood metabolites associated with reduced kidney function.bioRxiv : the preprint server for biology · 2024Article
- Constipation anti-aging effects by dairy-based lactic acid bacteria.Journal of animal science and technology · 2024Article
- Risk relationship between leukocyte telomere length and constipation: a Mendelian randomization study.Frontiers in medicine · 2023Article
- Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice.Communications biology · 2022Article
- Age-related differences of γ-aminobutyric acid (GABA)ergic transmission in human colonic smooth muscle.Neurogastroenterology and motility · 2022Article
- Status of Constipation and Its Association with Sarcopenia in Older Adults: A Population-Based Cohort Study.International journal of environmental research and public health · 2021Article
- The Aged Intestine: Performance and Rejuvenation.Aging and disease · 2021Review
- Molecular Characterization of Constipation Disease as Novel Phenotypes in CRISPR-Cas9-Generated Leptin Knockout Mice with Obesity.International journal of molecular sciences · 2020Article
- Aging, melatonin biosynthesis, and circadian clockworks in the gastrointestinal system of the laboratory mouse.Physiological genomics · 2019Article
- Article
- Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly.Oncotarget · 2018Article
- Article
- Carbon monoxide contributes to the constipating effects of granisetron in rat colon.World journal of gastroenterology · 2016Article
- Older Is Not Wiser, Immunologically Speaking: Effect of Aging on Host Response to Clostridium difficile Infections.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Constipation is a common problem in the elderly, and abnormalities in the neural innervation of the colon play a significant role in abnormalities in colonic motility leading to delayed colonic transit. The scope of this review encompasses the latest advances to enhance our understanding of the aging colon with emphasis on enteric neurodegeneration, considered a likely cause for the development of constipation in the aging gut in animal models. Neural innervation of the colon and the effects of aging on intrinsic and extrinsic nerves innervating the colonic smooth muscle is discussed. Evidence supporting the concept that neurologic disorders, such as Parkinson's disease, not only affect the brain but also cause neurodegeneration within the enteric nervous system leading to colonic dysmotility is presented. Further research is needed to investigate the influence of aging on the gastrointestinal tract and to develop novel approaches to therapy directed at protecting the enteric nervous system from neurodegeneration.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.