ArticleHistochemistry and cell biology2010
Satellite cell heterogeneity with respect to expression of MyoD, myogenin, Dlk1 and c-Met in human skeletal muscle: application to a cohort of power lifters and sedentary men.
Article in Histochemistry and cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Protein Supplementation Does Not Affect Myogenic Adaptations to Resistance Training.Medicine and science in sports and exercise · 2017Trial
- Ciliary neurotrophic factor slows axonal transport of signalling endosomes.Brain communications · 2026Article
- Global MyoG research 2004-2024: a bibliometric analysis of trends and translational implications.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Myotube Formation and Cellular Fusion Are Diminished Due to Low Birth Weight in Piglets.International journal of molecular sciences · 2025Article
- Article
- Emerging Roles of DLK1 in the Stem Cell Niche and Cancer Stemness.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Review
- Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor.Stem cell research & therapy · 2021Article
- Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis.eLife · 2020Article
- Overfeeding and Substrate Availability, But Not Age or BMI, Alter Human Satellite Cell Function.Nutrients · 2020Article
- Muscle Microbiopsy to Delineate Stem Cell Involvement in Young Patients: A Novel Approach for Children With Cerebral Palsy.Frontiers in physiology · 2020Article
- Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis.Histochemistry and cell biology · 2019Article
- Protein Availability and Satellite Cell Dynamics in Skeletal Muscle.Sports medicine (Auckland, N.Z.) · 2018Review
- Molecular and functional heterogeneity of early postnatal porcine satellite cell populations is associated with bioenergetic profile.Scientific reports · 2017Article
- Meeting the meat: delineating the molecular machinery of muscle development.Journal of animal science and technology · 2016Review
- Muscle Satellite Cells: Exploring the Basic Biology to Rule Them.Stem cells international · 2016Review
- Early myogenic responses to acute exercise before and after resistance training in young men.Physiological reports · 2015Article
- Satellite cells in human skeletal muscle plasticity.Frontiers in physiology · 2015Review
- Myogenic progenitors and imaging single-cell flow analysis: a model to study commitment of adult muscle stem cells.Journal of muscle research and cell motility · 2014Article
- Acute low-load resistance exercise with and without blood flow restriction increased protein signalling and number of satellite cells in human skeletal muscle.European journal of applied physiology · 2013Article
- Satellite cells and the muscle stem cell niche.Physiological reviews · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human satellite cells (SCs) are heterogeneous with respect to markers for their identification in the niche between the muscle fibre plasma membrane and its basal lamina. We have previously shown that, in biopsies from highly competitive power lifters, power lifters with long-term use of anabolic steroids and a population of healthy sedentary men, antibodies against the neuronal cell adhesion molecule (NCAM) and the paired box transcription factor Pax7 together label 94% of the SCs, NCAM alone labels 4% and Pax7 alone labels 1%. In the present study, we have further studied these biopsies with four markers related to SC activation and differentiation. Our study unequivocally shows that staining for MyoD and myogenin are present in nuclei of SCs and of myoblasts and myotubes in areas of muscle fibre regeneration. Staining for c-Met was observed in a proportion of Pax7+ SCs. However, widespread labelling of the sarcolemma precluded the quantification of c-Met+/Pax7+ SCs and the use of c-Met as a reliable SC marker. Pax7+ SCs labelled by anti-Delta like1 (Dlk1) were present in all samples but in variable proportions, whereas muscle progenitor cells related to repair were Dlk1⁻. Staining for Dlk1 was also observed in Pax7⁻ interstitial cells and in the cytoplasm of some small muscle fibres. Interestingly, the proportion of Dlk1+/Pax7+ SCs was significantly different between the groups of power lifters. Thus, our study confirms that human SCs show marked heterogeneity and this is discussed in terms of SC activation, myonuclei turnover, muscle fibre growth and muscle fibre damage and repair.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.