ReviewCurrent diabetes reports2010
From genetic association to molecular mechanism.
Review in Current diabetes reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes.PloS one · 2017Pooled it
- Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses.Human molecular genetics · 2012Pooled it
- Role of Leptin in Inflammation and Vice Versa.International journal of molecular sciences · 2020Review
- Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene.The Journal of clinical endocrinology and metabolism · 2015Article
- Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury.Neurogenetics · 2015Article
- Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Nature genetics · 2014Article
- Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes.Current diabetes reviews · 2014Review
- Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.Current diabetes reports · 2013Article
- The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis.PloS one · 2013Article
- What will diabetes genomes tell us?Current diabetes reports · 2012Review
- Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats.Physiological genomics · 2012Article
- Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.Cell metabolism · 2012Article
- Genetic variants in potassium channels are associated with type 2 diabetes in a Mongolian population.Journal of diabetes · 2012Article
- Article
- Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.Diabetologia · 2012Article
- Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons.Molecular neurodegeneration · 2011Article
- Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations.Diabetologia · 2011Article
- Association between genetics of diabetes, coronary artery disease, and macrovascular complications: exploring a common ground hypothesis.The review of diabetic studies : RDS · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Over the past 3 years, there has been a dramatic increase in the number of confirmed type 2 diabetes (T2D) susceptibility loci, most arising through the implementation of genome-wide association studies (GWAS). However, progress toward the understanding of disease mechanisms has been slowed by modest effect sizes and the fact that most GWAS signals map away from coding sequence: the presumption is that their effects are mediated through regulation of nearby transcripts, but the identities of the genes concerned are often far from clear. In this review we describe the progress that has been made to date in translating association signals into molecular mechanisms with a focus on the most tractable signals (eg, KCNJ11/ABCC8, SLC30A8, GCKR) and those in which human, animal, and cellular models (FTO, TCF7L2, G6PC2) have provided insights into the role in T2D pathogenesis. Finally, the challenges for the field with the advent of genome-scale next-generation resequencing efforts are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.