ReviewJournal of perinatology : official journal of the California Perinatal Association2010
Chorioamnionitis: a multiorgan disease of the fetus?
Review in Journal of perinatology : official journal of the California Perinatal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 5 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in immunology · 2020Pooled it
- Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants: A Systematic Review, Meta-analysis, and Metaregression.JAMA network open · 2019Pooled it
- Chorioamnionitis as a risk factor for retinopathy of prematurity: An updated systematic review and meta-analysis.PloS one · 2018Pooled it
- Chorioamnionitis appears not to be a Risk Factor for Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis.Scientific reports · 2016Pooled it
- Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- The fetoneonatology fellowship: a unified subspecialty for the fetal-neonatal continuum.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Association of vitamin D status with novel hemogram-derived inflammatory indices in preterm infants.BMC pediatrics · 2026Article
- Gestational age-dependent effects of intrauterine inflammation, delivery mode, and fetal growth on respiratory morbidity in preterm neonates.Frontiers in pediatrics · 2026Article
- Development and validation of a nomogram for predicting necrotizing enterocolitis in premature infants with early-onset sepsis.Scientific reports · 2025Article
- AntenatalInternational journal of molecular sciences · 2024Article
- Antenatal Ureaplasma infection induces ovine small intestinal goblet cell defects: a strong link with NEC pathology.Tissue barriers · 2023Article
- Mild/asymptomatic COVID-19 in unvaccinated pregnant mothers impairs neonatal immune responses.JCI insight · 2023Article
- Utilizing Amniotic Fluid Metabolomics to Monitor Fetal Well-Being: A Narrative Review of the Literature.Cureus · 2023Review
- Association of Funisitis with Short-Term Outcomes of Prematurity: A Frequentist and Bayesian Meta-Analysis.Antioxidants (Basel, Switzerland) · 2023Review
- Effects of multiple pro-inflammatory stimuliFrontiers in immunology · 2023Article
- Risk factors and postnatal biomarkers for acute placental inflammatory lesions and intrauterine infections in preterm infants.European journal of pediatrics · 2022Article
- Antenatal diagnosis of chorioamnionitis: A review of the potential role of fetal and placental imaging.Prenatal diagnosis · 2022Review
- A20 Is Increased in Fetal Lung in a Sheep LPS Model of Chorioamnionitis.Oxidative medicine and cellular longevity · 2022Article
- The Physiologic Significance of Early Urinary Intestinal Fatty Acid Binding Protein Levels in Preterm Infants: A Prospective Cohort Study.Children (Basel, Switzerland) · 2021Article
- Organ-on-a-chip technology for the study of the female reproductive system.Advanced drug delivery reviews · 2021Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterial infection of chorion and amnion is a common finding in premature delivery and is referred to as chorioamnionitis. As the mother rarely shows symptoms of a systemic inflammation, the course of chorioamnionitis is frequently asymptomatic and chronic. In contrast, the fetal inflammatory response syndrome represents a separate phenomenon, including umbilical inflammation and increased serum levels of proinflammatory cytokines in the fetus. Ascending maternal infections frequently lead to systemic fetal inflammatory reaction. Clinical studies have shown that antenatal exposure to inflammation puts the extremely immature neonates at a high risk for worsening pulmonary, neurological and other organ development. Interestingly, the presence of chorioamnionitis is associated with a lower rate of neonatal mortality in extremely immature newborns. In the following review, the pathogeneses of inflammation-associated perinatal morbidity are outlined. The concept of fetal multiorganic disease during intrauterine infection is introduced and discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.