ArticleInternational journal of obesity (2005)2011
African genetic admixture is associated with body composition and fat distribution in a cross-sectional study of children.
Article in International journal of obesity (2005), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- Ethnic Mixture and Body Mass Index as Modifiers of Breast Cancer Risk among Native Hawaiian Women: Insights from the Multiethnic Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Relationship between body mass index and cardiometabolic health in a multi-ethnic population: A project baseline health study.American journal of preventive cardiology · 2024Article
- Observational
- Body composition data show that high BMI centiles overdiagnose obesity in children aged under 6 years.The American journal of clinical nutrition · 2022Article
- Genetic risk score prediction of leg fat and insulin sensitivity differs by race/ethnicity in early pubertal children.Pediatric obesity · 2021Article
- Trajectories of adiposity indicators and association with asthma and lung function in urban minority children.The Journal of allergy and clinical immunology · 2021Article
- Approach to the Patient: Management of the Post-Bariatric Surgery Patient With Weight Regain.The Journal of clinical endocrinology and metabolism · 2021Review
- Evaluation of Ethnic Variations in Visceral, Subcutaneous, Intra-Pancreatic, and Intra-Hepatic Fat Depositions by Magnetic Resonance Imaging among New Zealanders.Biomedicines · 2020Article
- Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions.JAMA pediatrics · 2020Review
- Relationship of Anthropometric Indices to Abdominal Body Composition: A Multi-Ethnic New Zealand Magnetic Resonance Imaging Study.Journal of clinical medicine research · 2019Article
- Weight Recidivism After Roux-en-Y Gastric Bypass Surgery: An 11-Year Experience in a Multiethnic Medical Center.Obesity (Silver Spring, Md.) · 2019Article
- Taq1a polymorphism (rs1800497) is associated with obesity-related outcomes and dietary intake in a multi-ethnic sample of children.Pediatric obesity · 2019Article
- Higher n-6:n-3 Fatty Acid Intake Is Associated with Decreased Cardiometabolic Risk Factors in a Racially Diverse Sample of Children.Current developments in nutrition · 2018Article
- Association of psychosocial stressors with metabolic syndrome severity among African Americans in the Jackson Heart Study.Psychoneuroendocrinology · 2018Article
- Anthropometric discriminators of type 2 diabetes among White and Black American adults.Journal of diabetes · 2017Article
- Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study.Genes & nutrition · 2017Article
- Cardio-metabolic parameters are associated with genetic admixture estimates in a pediatric population from Colombia.BMC genetics · 2016Article
- The role of racial genetic admixture with endometrial cancer outcomes: An NRG Oncology/Gynecologic Oncology Group study.Gynecologic oncology · 2016Article
- The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies.Frontiers in genetics · 2016Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveAlthough differences in body composition parameters among African American (AA), Hispanic American (HA) and European American (EA) children are well documented, the factors underlying these differences are not completely understood. Environmental and genetic contributors have been evaluated as contributors to observed differences. This study evaluated the extent to which African or European ancestral genetic background influenced body composition and fat distribution in 301 peripubertal AA (n = 107), HA (n = 79) and EA (n = 115) children aged 7-12.
designEstimates of African admixture (AFADM) and European admixture (EUADM) were obtained for every subject using 142 ancestry informative DNA markers. Dual energy X-ray absorptiometry and computed tomography scanning were used to determine body composition and abdominal fat distribution, respectively. Multiple regression models were conducted to evaluate the contribution of admixture estimates to body composition and fat distribution.
resultsGreater AFADM was associated with lower fat mass (P = 0.0163), lower total abdominal adipose tissue (P = 0.0006), lower intra-abdominal adipose tissue (P = 0.0035), lower subcutaneous abdominal adipose tissue (P = 0.0115) and higher bone mineral content (BMC) (P = 0.0253), after adjusting for socio-economic status, sex, age, height, race/ethnicity and pubertal status. Greater EUADM was associated with lower lean mass (LM) (P = 0.0056).
conclusionThese results demonstrate that ancestral genetic background contributes to racial/ethnic differences in body composition above and beyond the effects of racial/ethnic classification and suggest a genetic contribution to total body fat accumulation, abdominal adiposity, LM and BMC.
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