ReviewMolecules (Basel, Switzerland)2010
Kinin receptor antagonists as potential neuroprotective agents in central nervous system injury.
Review in Molecules (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.British journal of pharmacology · 2025Review
- The temporal dynamic of bradykinin type 2 receptor effects reveals its neuroprotective role in the chronic phase of cerebral and retinal ischemic injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.British journal of pharmacology · 2023Article
- Therapeutic efficacy of topical blockade of substance P in experimental allergic red eye.The ocular surface · 2022Article
- Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer's Disease Pathological Characteristics in a Transgenic Mouse Model.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice.Journal of neurochemistry · 2020Article
- COVID-19 Usurps Host Regulatory Networks.Frontiers in pharmacology · 2020Review
- Protein kinase Cε regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression.Scientific reports · 2018Article
- Primary Role for Kinin BMolecular neurobiology · 2017Article
- Serum Levels of Substance P and Mortality in Patients with a Severe Acute Ischemic Stroke.International journal of molecular sciences · 2016Article
- Experimental diffuse brain injury results in regional alteration of gross vascular morphology independent of neuropathology.Brain injury · 2016Article
- Review
- Immunomodulation in stem cell differentiation into neurons and brain repair.Stem cell reviews and reports · 2015Review
- Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study.Drug design, development and therapy · 2015Article
- Distribution and morphology of calcitonin gene-related peptide and substance P immunoreactive axons in the whole-mount atria of mice.Autonomic neuroscience : basic & clinical · 2014Article
- NK1 receptor blockade is ineffective in improving outcome following a balloon compression model of spinal cord injury.PloS one · 2014Article
- The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.British journal of pharmacology · 2013Article
- Blocking neurogenic inflammation for the treatment of acute disorders of the central nervous system.International journal of inflammation · 2013Article
- Urine proteins identified by two-dimensional differential gel electrophoresis facilitate the differential diagnoses of scrapie.PloS one · 2013Article
- The pathophysiology of brain swelling associated with subdural hemorrhage: the role of the trigeminovascular system.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.