ArticleMolecules (Basel, Switzerland)2010
Screening of filamentous fungi to identify biocatalysts for lupeol biotransformation.
Article in Molecules (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cytotoxic Triterpenes from Argan Pulp (Molecules (Basel, Switzerland) · 2026Article
- Manganese Porphyrin-Catalyzed One-Pot Oxidation of Lupeol: Efficient Conversion of Its Terminal Alkene Into Carboxylic Acids.Chemistry & biodiversity · 2026Article
- Antibacterial and Antioxidant Activities of Triterpenoids Isolated from EndemicAdvances in pharmacological and pharmaceutical sciences · 2024Article
- A GC-MS Chemotaxonomic Study on Lipophilic Compounds in the Bark ofMetabolites · 2023Article
- Inactivation of β-Lapachone Cytotoxicity by Filamentous Fungi that Mimic the Human Blood Metabolism.European journal of drug metabolism and pharmacokinetics · 2017Article
- Direct Biotransformation of Dioscin into Diosgenin in Rhizome of Dioscorea zingiberensis by Penicillium dioscin.Indian journal of microbiology · 2015Article
- Microbial-catalyzed biotransformation of multifunctional triterpenoids derived from phytonutrients.International journal of molecular sciences · 2014Review
- Anticariogenic properties of ent-pimarane diterpenes obtained by microbial transformation.Molecules (Basel, Switzerland) · 2010Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of the study was to evaluate the ability of filamentous fungi to biotransform the pentacyclic triterpene lupeol. The microbial transformations were carried out in shake flasks in different media. Experiments were also run with control flasks. Samples of each culture were taken every 24 hours, extracted with ethyl acetate, and analyzed by GC-MS. The biotransformation of lupeol by Aspergillus ochraceus and Mucor rouxii afforded two compounds in each culture, which were detected in the cultures developed for more than seven days only in the Koch's K1 medium. The obtained data demonstrated that A. ochraceus is a good biocatalyst to introduce double bonds in the lupeol structure, whereas M. rouxii exhibits ability to biocatalyze oxygen insertions in that pentacyclic triterpene. Mass spectrometry was demonstrated to be an efficient analytical method to select promising biocatalysts for the compound investigated in this study. The biotransformation processes were influenced by the culture medium and incubation period. The obtained results open the perspective of using A. ochraceus and M. rouxii in pentacyclic triterpene biotransformations.
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