ArticleJournal of genetics2010
Conservation and sex-specific splicing of the doublesex gene in the economically important pest species Lucilia cuprina.
Article in Journal of genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- CRISPR/Cas9-Mediated Mutagenesis of Sex-SpecificCells · 2022Article
- Conditional knockdown of transformer in sheep blow fly suggests a role in repression of dosage compensation and potential for population suppression.PLoS genetics · 2021Article
- Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs.Communications biology · 2020Article
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
- Article
- A pipeline for the de novo assembly of the Themira biloba (Sepsidae: Diptera) transcriptome using a multiple k-mer length approach.BMC genomics · 2014Article
- Development and evaluation of male-only strains of the Australian sheep blowfly, Lucilia cuprina.BMC genetics · 2014Review
- Article
- Article
- Doublesex target genes in the red flour beetle, Tribolium castaneum.Scientific reports · 2012Article
- Positive and purifying selection influence the evolution of doublesex in the Anastrepha fraterculus species group.PloS one · 2012Article
- Organisation and expression of a cluster of yolk protein genes in the Australian sheep blowfly, Lucilia cuprina.Genetica · 2011Article
- Doublesex: a conserved downstream gene controlled by diverse upstream regulators.Journal of genetics · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic control of sex determination in insects has been best characterized in Drosophila melanogaster, where the master gene Sxl codes for RNA that is sex specifically spliced to produce a functional protein only in females. SXL regulates the sex-specific splicing of transformer (tra) RNA which, in turn, regulates the splicing of dsx RNA to produce functional male and female proteins. In the Australian sheep blowfly (Lucilia cuprina), the tra gene (Lctra) is required for female development and Lctra transcripts are sex-specifically spliced such that only female Lctra mRNA codes for functional protein. In males, a factor encoded by the Y-linked male determining gene is thought to prevent the female-mode of splicing of Lctra RNA. To further our understanding of the sex determination regulatory hierarchy in L. cuprina, we have isolated the dsx gene (Lcdsx) from this species. We found that the Lcdsx transcripts are sex-specifically spliced in a similar manner as their counterparts in D. melanogaster, housefly and tephritids. The LcDSX proteins are well conserved and the male form of DSX contains a motif encoded by a male-specific exon that is within the female-specific intron. This intron/exon arrangement had previously been found only in the housefly dsx gene, suggesting this may be a unique feature of dsx genes of Calyptratae species.
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