ArticleAging2010
TP53 and MTOR crosstalk to regulate cellular senescence.
Article in Aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 80 citations in OpenAlex.
- Targeting Ferroptosis to Eliminate Senescent Cells: Mechanisms and Therapeutic Potential.Aging and disease · 2025Review
- MicroRNA-137 inhibits pituitary prolactinoma proliferation by targeting AKT2.Journal of endocrinological investigation · 2023Article
- Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.Scientific reports · 2021Article
- Article
- Integrative analysis of methylation and transcriptional profiles to predict aging and construct aging specific cross-tissue networks.BMC systems biology · 2016Article
- cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response.Cell cycle (Georgetown, Tex.) · 2016Article
- Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion.Oncotarget · 2016Article
- Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment.Cell cycle (Georgetown, Tex.) · 2016Article
- Review
- The Intricate Interplay between Mechanisms Underlying Aging and Cancer.Aging and disease · 2015Review
- Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin.BioMed research international · 2015Review
- Trial Watch: Radioimmunotherapy for oncological indications.Oncoimmunology · 2014Review
- Latest progress in tyrosine kinase inhibitors.Oncotarget · 2014Article
- mTOR pathway in colorectal cancer: an update.Oncotarget · 2014Review
- Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms.Frontiers in endocrinology · 2014Review
- Radiation-Induced Bystander Response: Mechanism and Clinical Implications.Advances in wound care · 2014Review
- Rapamycin induces pluripotent genes associated with avoidance of replicative senescence.Cell cycle (Georgetown, Tex.) · 2013Article
- TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Cell death & disease · 2013Review
- Dysregulation of the mTOR pathway in p53-deficient mice.Cancer biology & therapy · 2013Article
- Immunosuppressants in cancer prevention and therapy.Oncoimmunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.