ArticleScience signaling2010
Beta-adrenergic regulation of the L-type Ca2+ channel Ca(V)1.2 by PKA rekindles excitement.
Article in Science signaling, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models.Scientific reports · 2023Article
- Sympathetic Nervous System Regulation of Cardiac Calcium Channels.Handbook of experimental pharmacology · 2023Article
- Animal Models to Study Cardiac Arrhythmias.Circulation research · 2022Review
- Use of Proximity Labeling in Cardiovascular Research.JACC. Basic to translational science · 2021Review
- GRK5 Controls SAP97-Dependent Cardiotoxic βCirculation research · 2020Article
- Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of CaThe Journal of biological chemistry · 2018Article
- Locomotion Behavior Is Affected by the GαGenetics · 2017Article
- Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.Science signaling · 2017Article
- Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.The EMBO journal · 2016Article
- The Role of IL-17 and TH17 Cells in the Bone Catabolic Activity of PTH.Frontiers in immunology · 2016Review
- IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.Cell metabolism · 2015Article
- Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.The Journal of cell biology · 2014Article
- Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes.Neurochemistry international · 2013Review
- PKA controls calcium influx into motor neurons during a rhythmic behavior.PLoS genetics · 2013Article
- Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets.The Journal of clinical investigation · 2012Article
- A-kinase anchoring proteins: scaffolding proteins in the heart.American journal of physiology. Heart and circulatory physiology · 2011Review
- Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2.Biochemistry · 2010Article
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Abstract
When we are frightened, our hearts beat more rapidly and forcefully so we can fight more intensely or run away faster. This fight-or-flight response is triggered by the release of norepinephrine from neurons of the sympathetic nervous system. Norepinephrine activates the classic β-adrenergic receptor-heterotrimeric G(s) protein-adenylyl cyclase-adenosine 3',5'-monophosphate-protein kinase A (PKA) signaling cascade. One of the main PKA targets implicated in this response is the L-type Ca2+ channel Ca(V)1.2, which mediates Ca2+ influx into cardiomyocytes. Because of its central function in regulating heartbeat, and because the underlying molecular mechanism has remained elusive, understanding the regulation of Ca(V)1.2 has been considered the holy grail for the field of channel regulation. New evidence from the quest to solve the mystery of Ca(V)1.2 regulation has revealed that reproducible reconstitution of this regulation in heterologous cells requires a perfect balance of the ratio of Ca(V)1.2 to A-kinase anchor proteins (AKAPs). Proteolytic processing of the cytosolic C terminus of the central, pore-forming α₁1.2 subunit of Ca(V)1.2 contributed to its regulation by PKA, and Ser(1700) in the C terminus of the α₁1.2 subunit emerged as the relevant PKA phosphorylation site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.