ArticleNucleic acids research2011
Splicing of the Sinorhizobium meliloti RmInt1 group II intron provides evidence of retroelement behavior.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Prokaryotic reverse transcriptases: from retroelements to specialized defense systems.FEMS microbiology reviews · 2021Review
- Visualizing group II intron dynamics between the first and second steps of splicing.Nature communications · 2020Article
- Article
- Contribution of Mobile Group II Introns toFrontiers in microbiology · 2018Review
- Mobile Group II Introns as Ancestral Eukaryotic Elements.Trends in genetics : TIG · 2017Review
- Recent horizontal transfer, functional adaptation and dissemination of a bacterial group II intron.BMC evolutionary biology · 2016Article
- The early events underlying genome evolution in a localized Sinorhizobium meliloti population.BMC genomics · 2016Article
- Localization of a bacterial group II intron-encoded protein in human cells.Scientific reports · 2015Article
- Inactivation of group II intron RmInt1 in the Sinorhizobium meliloti genome.Scientific reports · 2015Article
- In vitro characterization of the splicing efficiency and fidelity of the RmInt1 group II intron as a means of controlling the dispersion of its host mobile element.RNA (New York, N.Y.) · 2014Article
- Complete Genome Sequence of the RmInt1 Group II Intronless Sinorhizobium meliloti Strain RMO17.Genome announcements · 2014Article
- Article
- Insights into the strategies used by related group II introns to adapt successfully for the colonisation of a bacterial genome.RNA biology · 2014Review
- Predicted group II intron lineages E and F comprise catalytically active ribozymes.RNA (New York, N.Y.) · 2013Article
- Now on display: a gallery of group II intron structures at different stages of catalysis.Mobile DNA · 2013Article
- Article
- Relevance of the branch point adenosine, coordination loop, and 3' exon binding site for in vivo excision of the Sinorhizobium meliloti group II intron RmInt1.The Journal of biological chemistry · 2011Article
- Exon sequence requirements for excision in vivo of the bacterial group II intron RmInt1.BMC molecular biology · 2011Article
- Spread of the group II intron RmInt1 and its insertion sequence target sites in the plant endosymbiont Sinorhizobium meliloti.Mobile genetic elements · 2011Article
- Use of RmInt1, a group IIB intron lacking the intron-encoded protein endonuclease domain, in gene targeting.Applied and environmental microbiology · 2011Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group II introns act as both large catalytic RNAs and mobile retroelements. They are found in organelle and bacterial genomes and are spliced via a lariat intermediate, in a mechanism similar to that of spliceosomal introns. However, their distribution and insertion patterns, particularly for bacterial group II introns, suggest that they function and behave more like retroelements than organelle introns. RmInt1 is an efficient mobile intron found within the ISRm2011-2 insertion sequence in the symbiotic bacterium Sinorhizobium meliloti. This group II intron is excised, in vivo and in vitro, as intron lariats. However, the complete splicing reaction in vivo remains to be elucidated. A lacZ reporter gene system, northern blotting and real-time reverse transcription were carried out to investigate RmInt1 splicing activity. Splicing efficiency of 0.07 ± 0.02% was recorded. These findings suggest that bacterial group II introns function more like retroelements than spliceosomal introns. Their location is consistent with a role for these introns in preventing the spread of other potentially harmful mobile elements in bacteria.
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